Chapter 28. A Preamble to Aglycone Reconstruction for Membrane-Presented Glycolipid Mimics

  1. Prof. Dr. Chi-Huey Wong
  1. Murugesapillai Mylvaganam,
  2. Clifford A. Lingwood

Published Online: 28 JAN 2005

DOI: 10.1002/3527602437.ch28

Book Title

Carbohydrate-Based Drug Discovery

Carbohydrate-Based Drug Discovery

Additional Information

How to Cite

Mylvaganam, M. and Lingwood, C. A. (2005) A Preamble to Aglycone Reconstruction for Membrane-Presented Glycolipid Mimics, in Carbohydrate-Based Drug Discovery (ed C.-H. Wong), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527602437.ch28

Editor Information

  1. Ernest W. Hahn Chair in Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines RoadLa Jolla, CA 92037, USA

Publication History

  1. Published Online: 28 JAN 2005
  2. Published Print: 26 AUG 2003

ISBN Information

Print ISBN: 9783527306329

Online ISBN: 9783527602438

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CHAPTER TOOLS

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Keywords:

  • aglycone reconstruction;
  • membrane-presented glycolipid mimics;
  • ceramide subtype composition;
  • lipid replacement;
  • structural motifs;
  • ceramide subtype-depending binding;
  • Hsp70;
  • ceramide-cholesterol composition;
  • adamantyl-acyl ceramide

Summary

  • Introduction

  • The Role of Ceramide Subtype Composition

  • Effects of Ceramide Subtype Composition in the Binding of Gb3Cer to Verotoxins

  • Hypothesis Regarding Lipid Replacement Structural Motifs (LRSMs)

  • Effect of Replacement of GSL Fatty Acyl Chains with Rigid, Non-Planar Hydrophobic Groups

  • Ada-Gb3Cer, a Functional Mimic of Membrane Presented Gb3Cer for VT Binding

  • Ceramide Subtype-Dependent Binding of Heat Shock Protein Hsp70 to Sulfogalactosyl Ceramide

  • Adamantyl-Acyl Ceramide is a Functional Replacement for a Ceramide-Cholesterol Composition: A Study with HIV Coat Protein gp120

  • Acknowledgement

  • References

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