Chapter 30. Carbohydrate-Based Treatment of Cancer Metastasis

  1. Prof. Dr. Chi-Huey Wong
  1. Reiji Kannagi

Published Online: 28 JAN 2005

DOI: 10.1002/3527602437.ch30

Book Title

Carbohydrate-Based Drug Discovery

Carbohydrate-Based Drug Discovery

Additional Information

How to Cite

Kannagi, R. (2005) Carbohydrate-Based Treatment of Cancer Metastasis, in Carbohydrate-Based Drug Discovery (ed C.-H. Wong), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527602437.ch30

Editor Information

  1. Ernest W. Hahn Chair in Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines RoadLa Jolla, CA 92037, USA

Publication History

  1. Published Online: 28 JAN 2005
  2. Published Print: 26 AUG 2003

ISBN Information

Print ISBN: 9783527306329

Online ISBN: 9783527602438

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Keywords:

  • carbohydrate-based treatment of cancer metastasis;
  • carbohydrate determinants;
  • cancer metastasis;
  • tumor angiogenesis;
  • cancer-endothelial interaction;
  • monoclonal antibodies;
  • inhibition of cancer cell-endothelial interaction;
  • inhibitors of selectin-mediated cell adhesion;
  • regulation of selectin expression;
  • enhanced expression;
  • sialyl Lex and sialyl Lea

Summary

  • Implication of Carbohydrate Determinants in Cancer Metastasis

    • Distant Hematogenous Metastasis of Cancer Cells

    • Multiple Organ Infiltration of Leukemic Cells

    • Lymph Node Infiltration Mediated by L-Selectin

    • Other Carbohydrate Determinants Involved in Distant Metastasis

  • Tumor Angiogenesis and Cancer-Endothelial Interaction

    • Possible Involvement of Selectin-Mediated Cell Adhesion in Tumor Angiogenesis

    • Roles of Humoral Factors and Cell Adhesion Molecules in Tumor Angiogenesis

  • Use of Monoclonal Antibodies for Inhibition of Cancer Cell-Endothelial Interaction

    • Diversity of Selectin Ligand Expression on Cancer Cells

    • Internally Fucosylated Ligands for Selectins

    • Sulfated Ligands for Selectins

    • O-Acetylation and Other Sialic Acid Modifications in Carbohydrate Ligands

  • Inhibitors of Selectin-Mediated Cell Adhesion

    • Use of Carbohydrate Derivatives

    • Use of Peptide Mimetics

  • Regulation of Selectin Expression on Endothelial Cells

    • Enhanced E-Selectin Expression on Vascular Beds in Cancer Patients

    • Factors Affecting Endothelial E-Selectin Expression in Patients with Cancers

    • Chemoprophylaxis of Cancer Metastasis

  • Enhanced Expression of Sialyl Lex and Sialyl Lea in Malignant Cells and its Modulation

    • Fucosyltransferases Involved in Sialyl Lea and Sialyl Lex Synthesis and Antisense Gene Therapy

    • Therapy Targeting Transcriptional Regulation of Fucosyltransferases VII and IV in Cancer and Leukemia

    • Cancer-Associated Alteration of Sialyltransferase Isoenzymes

    • Sialyltransferase and the Concept of Cancer-Associated Incomplete Synthesis of Carbohydrate Determinants

    • Sulfotransferase and Differentiation Therapy of Cancer with Histone Deacetylase Inhibitors

    • Effect of Sialidases and Membrane Recycling on Sialyl Lex/a Expression in Cancer

    • Substrate Competition with A- and B-Transferases and DNA Methylation

    • Altered Carbohydrate Intermediate Metabolism and Sialyl Lex/a Expression in Cancer – Possible Relation to Warburg Theory

  • References

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