Chapter 31. N-Acetylneuraminic Acid Derivatives and Mimetics as Anti-Influenza Agents

  1. Prof. Dr. Chi-Huey Wong
  1. Robin Thomson,
  2. Mark von Itzstein

Published Online: 28 JAN 2005

DOI: 10.1002/3527602437.ch31

Book Title

Carbohydrate-Based Drug Discovery

Carbohydrate-Based Drug Discovery

Additional Information

How to Cite

Thomson, R. and von Itzstein, M. (2005) N-Acetylneuraminic Acid Derivatives and Mimetics as Anti-Influenza Agents, in Carbohydrate-Based Drug Discovery (ed C.-H. Wong), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527602437.ch31

Editor Information

  1. Ernest W. Hahn Chair in Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines RoadLa Jolla, CA 92037, USA

Publication History

  1. Published Online: 28 JAN 2005
  2. Published Print: 26 AUG 2003

ISBN Information

Print ISBN: 9783527306329

Online ISBN: 9783527602438

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Keywords:

  • N-acetylneuraminic acid derivatives;
  • mimetics;
  • anti-influenza agents;
  • influenza virus sialidase;
  • influenza virus sialidase inhibitors

Summary

  • Introduction

    • Influenza, the Disease

    • The Virus

    • Influenza Virus Sialidase

  • Structure-Based Design of Inhibitors of Influenza Virus Sialidase

  • Structure/Activity Relationship Studies of N-Acetylneuraminic Acid-Based Influenza Virus Sialidase Inhibitors

    • C-4 Modifications

    • C-5 Modifications

    • C-6 Modifications

    • Glycerol Side Chain Modifications

    • Glycerol Side Chain Replacement

  • Concluding Remarks

  • Acknowledgements

  • References

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