Chapter 32. Modified and Modifying Sugars as a New Tool for the Development of Therapeutic Agents – The Biochemically Engineered N-Acyl Side Chain of Sialic Acid: Biological Implications and Possible Uses in Medicine

  1. Prof. Dr. Chi-Huey Wong
  1. Rüdiger Horstkorte,
  2. Oliver T. Keppler,
  3. Werner Reutter

Published Online: 28 JAN 2005

DOI: 10.1002/3527602437.ch32

Book Title

Carbohydrate-Based Drug Discovery

Carbohydrate-Based Drug Discovery

Additional Information

How to Cite

Horstkorte, R., Keppler, O. T. and Reutter, W. (2005) Modified and Modifying Sugars as a New Tool for the Development of Therapeutic Agents – The Biochemically Engineered N-Acyl Side Chain of Sialic Acid: Biological Implications and Possible Uses in Medicine, in Carbohydrate-Based Drug Discovery (ed C.-H. Wong), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527602437.ch32

Editor Information

  1. Ernest W. Hahn Chair in Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines RoadLa Jolla, CA 92037, USA

Publication History

  1. Published Online: 28 JAN 2005
  2. Published Print: 26 AUG 2003

ISBN Information

Print ISBN: 9783527306329

Online ISBN: 9783527602438

SEARCH

CHAPTER TOOLS

Get PDF (289K)

Keywords:

  • modified sugars;
  • modifying sugars;
  • biochemically engineered N-acyl side chain of sialic acid;
  • new tool for the development of therapeutic agents

Summary

  • Introduction

  • N-Acyl Side Chain-Modified Precursors of Sialic Acid

    • Biosynthetic Engineering of Cell Surface Sialic Acid as a Potent Tool for Study of Virus-Receptor Interactions

    • Immunotargeting of Tumor Cells Expressing Unnatural Polysialic Acids

    • Activation of Human T-Lymphocytes by ManProp

    • N-Acyl-Modified Sialic Acids can Stimulate Neural Cells

      • Stimulation of Glial Cells

      • Stimulation of Neurons

  • Outlook

  • Acknowledgements

  • Abbreviations

  • References

Get PDF (289K)