Chapter 6. Enzymatic Synthesis of Oligosaccharides

  1. Prof. Dr. Chi-Huey Wong
  1. Jianbo Zhang,
  2. Jun Shao,
  3. Prezemk Kowal,
  4. Peng George Wang

Published Online: 28 JAN 2005

DOI: 10.1002/3527602437.ch6

Book Title

Carbohydrate-Based Drug Discovery

Carbohydrate-Based Drug Discovery

Additional Information

How to Cite

Zhang, J., Shao, J., Kowal, P. and Wang, P. G. (2005) Enzymatic Synthesis of Oligosaccharides, in Carbohydrate-Based Drug Discovery (ed C.-H. Wong), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527602437.ch6

Editor Information

  1. Ernest W. Hahn Chair in Chemistry, The Scripps Research Institute, 10550 N. Torrey Pines RoadLa Jolla, CA 92037, USA

Publication History

  1. Published Online: 28 JAN 2005
  2. Published Print: 26 AUG 2003

ISBN Information

Print ISBN: 9783527306329

Online ISBN: 9783527602438

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Keywords:

  • enzymatic synthesis of oligosaccharides;
  • sugar nucleotide biosynthetic pathways;
  • enzymatic oligosaccharide synthesis processes

Summary

  • Introduction

  • Sugar Nucleotide Biosynthetic Pathways

    • Basic Principle

    • Regeneration Systems for nine Common Sugar Nucleotides

      • Regeneration Systems for UDP-Gal, UDP-Glc, UDP-GlcA and UDP-Xyl

      • Regeneration Systems for UDP-GlcNAc and UDP-GalNAc

      • Regeneration Systems for GDP-Man and GDP-Fuc

      • CMP-Neu5Ac Regeneration

    • Novel Energy Source in Sugar Nucleotide Regeneration

  • Enzymatic Oligosaccharide Synthesis Processes

    • Cell-Free Oligosaccharide Synthesis

      • Immobilized Glycosyltransferases and Water-Soluble Glycopolymer

      • Superbeads

    • Large-Scale Syntheses of Oligosaccharides with Whole Cells

      • Kyowa Hakko's Technology

      • Wang's Superbug

      • Other Whole Cell-Based Technologies

  • Future Directions

  • References

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