Chapter 7. Glycopeptides and Glycoproteins: Synthetic Chemistry and Biology

Summary

• Introduction

• The Glycosidic Linkage

• The Challenges of Glycopeptide Synthesis

• Synthesis of Preformed Glycosyl Amino Acids

  • N-Glycosides

  • O-Glycosides

    • O-Glycosyl Amino Acids bearing Mono- or Disaccharides

    • O-Glycosyl Amino Acids bearing Complex Carbohydrates

• Synthesis of Glycopeptides

  • N-Glycopeptide Synthesis in Solution

  • O-Glycopeptide Synthesis in Solution

  • Solid-Phase Synthesis of N-Glycopeptides

  • Solid-Phase Synthesis of O-Glycopeptides

• Biological and Biophysical Studies

  • Conformations of Glycopeptides

  • Glycopeptides as Substrates of Enzymes and Receptors

  • Glycopeptides and Cancer Immunotherapy

  • Glycopeptides and T Cell Recognition

• Summary and Outlook

• References