Chapter 27. Bioconjugated Silica Nanoparticles for Bioanalytical Applications

  1. Prof. Dr. Christof M. Niemeyer2 and
  2. Prof. Dr. Chad A. Mirkin3
  1. Timothy J. Drake,
  2. Xiaojun Julia Zhao and
  3. Weihong Tan

Published Online: 28 JAN 2005

DOI: 10.1002/3527602453.ch27

Nanobiotechnology: Concepts, Applications and Perspectives

Nanobiotechnology: Concepts, Applications and Perspectives

How to Cite

Drake, T. J., Julia Zhao, X. and Tan, W. (2004) Bioconjugated Silica Nanoparticles for Bioanalytical Applications, in Nanobiotechnology: Concepts, Applications and Perspectives (eds C. M. Niemeyer and C. A. Mirkin), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527602453.ch27

Editor Information

  1. 2

    Universität Dortmund, Fachbereich Chemie, Biologisch-Chemische Mikrostrukturtechnik, Otto-Hahn-Str. 6, 44227 Dortmund, Germany

  2. 3

    Department of Chemistry & Institute for Nanotechnology, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208-3113, USA

Author Information

  1. Center for Research at the Bio-nano Interface, Department of Chemistry, McKnight Brain Institute, University of Florida, Gainesville, FL 32611, USA

Publication History

  1. Published Online: 28 JAN 2005
  2. Published Print: 28 JAN 2004

ISBN Information

Print ISBN: 9783527306589

Online ISBN: 9783527602452

SEARCH

Keywords:

  • nanoanalytics;
  • bioconjugated silica nanoparticles;
  • bioanalytical applications;
  • fabrication;
  • dye-doped silica nanoparticles;
  • magnetic silica nanoparticles;
  • biofunctionalization of silica nanoparticles;
  • bioanalytical applications for silica nanoparticles

Summary

This chapter contains sections titled:

  • Overview

  • Methods

    • Fabrication

    • Particle Probes

      • Dye-doped Silica Nanoparticles

      • Magnetic Silica Nanoparticles

    • Biofunctionalization of Silica Nanoparticles

      • Amino-Group Cross-Linkage

      • Avidin–Biotin Linking Bridge

      • Disulfide-coupling Chemical Binding

      • Cyanogen Bromide Modification

    • Bioanalytical Applications for Silica Nanoparticles

      • Cellular Labeling/Detection

      • DNA Analysis

      • Ultrasensitive DNA Detection

  • Outlook