Chapter 15. A Multienzyme Complex Involved in Murein Synthesis of Escherichia coli

  1. Volkmar Braun2,
  2. Friedrich Götz3
  1. Moritz von Rechenberg,
  2. Waldemar Vollmer,
  3. Joachim-Volker Höltje

Published Online: 28 JAN 2005

DOI: 10.1002/3527602720.ch15

Book Title

Microbial Fundamentals of Biotechnology

Microbial Fundamentals of Biotechnology

Additional Information

How to Cite

von Rechenberg, M., Vollmer, W. and Höltje, J.-V. (2005) A Multienzyme Complex Involved in Murein Synthesis of Escherichia coli, in Microbial Fundamentals of Biotechnology (eds V. Braun and F. Götz), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527602720.ch15

Editor Information

  1. 2

    Mikrobiologie/Membranphysiologie, Universität Tübingen, Auf der Morgenstelle 28, D-72076 Tübingen, Germany

  2. 3

    Mikrobielle Genetik, Universität Tübingen, Waldhäuser Str. 70/8, D-72076 Tübingen, Germany

Author Information

  1. Max-Planck-Institut für Entwicklungsbiologie, Abt. Biochemie, Spemannstraße 35, D-72076 Tübingen, Germany

Publication History

  1. Published Online: 28 JAN 2005
  2. Published Print: 29 NOV 2001

ISBN Information

Print ISBN: 9783527306152

Online ISBN: 9783527602728

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CHAPTER TOOLS

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Keywords:

  • murein synthesis;
  • murein sacculus;
  • E. coli;
  • murein hydrolases and synthases

Summary

This chapter contains sections titled:

  • The murein sacculus, a “growing” molecule

  • Murein growth is accompanied by massive turnover

  • Enlargement and division of a stress bearing structure

  • Interaction of murein hydrolases and synthases as indicated by affinity chromatography

  • Dimerization of the bifunctional transpeptidase/transglycosylase PBP1B

  • Reconstitution of the core particle of a murein synthesizing machinery

  • Proposed structure of a hypothetical holoenzyme of murein synthesis

  • Recent insights in the mechanism of growth of the murein sacculus reveal novel targets for antibiotics

  • References

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