Chapter 24. The Catalytic Efficiency of Glycoside Hydrolases and Models of the Transition State Based on Substrate Related Inhibitors
- Yves Chapleur
Published Online: 28 JAN 2005
DOI: 10.1002/3527603239.ch24
Copyright © 1998 Wiley-VCH Verlag GmbH
Book Title
Carbohydrate Mimics: Concepts and Methods
Additional Information
How to Cite
Legler, G. (2005) The Catalytic Efficiency of Glycoside Hydrolases and Models of the Transition State Based on Substrate Related Inhibitors, in Carbohydrate Mimics: Concepts and Methods (ed Y. Chapleur), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603239.ch24
Editor Information
UMR CNRS 7565, Université Henri Poincaré-Nancy I, BP239, F-54506 Vandceuvre, France
Publication History
- Published Online: 28 JAN 2005
- Published Print: 12 NOV 1997
ISBN Information
Print ISBN: 9783527295265
Online ISBN: 9783527603237
- Summary
- Chapter
Keywords:
- glycoside hydrolases;
- transition state;
- substrate related inhibitors;
- catalytic efficiency;
- glycosyl cation-like transition state;
- active site carboxylate groups;
- aglycon site;
- N1-alkyl gluconaminidines
Summary
Introduction
Catalytic Efficiency and the Transition State
Evidence for a Glycosyl Cation-Like Transition State
Evidence for Active Site Carboxylate Groups
Interactions with the Aglycon Site
N1-Alkyl Gluconaminidines as “Perfect” Transition State Mimics?
Conclusion
References