Chapter 27. Synthesis of Nitrogen Containing Linkers for Antisense Oligonucleotides
- Yves Chapleur
Published Online: 28 JAN 2005
DOI: 10.1002/3527603239.ch27
Copyright © 1998 Wiley-VCH Verlag GmbH
Book Title
Carbohydrate Mimics: Concepts and Methods
Additional Information
How to Cite
Sanghvi, Y. S. (2005) Synthesis of Nitrogen Containing Linkers for Antisense Oligonucleotides, in Carbohydrate Mimics: Concepts and Methods (ed Y. Chapleur), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603239.ch27
Editor Information
UMR CNRS 7565, Université Henri Poincaré-Nancy I, BP239, F-54506 Vandceuvre, France
Publication History
- Published Online: 28 JAN 2005
- Published Print: 12 NOV 1997
ISBN Information
Print ISBN: 9783527295265
Online ISBN: 9783527603237
- Summary
- Chapter
Keywords:
- nitrogen containing linkers;
- antisense oligonucleotides;
- oximedimer;
- MI dimer;
- MMI dimer;
- MDH dimer;
- MOMI dimer;
- HMIM dimer
Summary
Introduction
Results
3′-C
![[BOND]](http://onlinelibrarystatic.wiley.com/undisplayable_characters/00f8ff.gif)
NO Linked Backbones Synthesis of OximeDimer 5
Synthesis of MI Dimer 6
Synthesis of MMI dimer 7
3′-C
NN Linked Backbone Synthesis of MDH dimer 8
3′-C
ON Linked Backbone Synthesis of MOMI dimer 9
3′-O
NC Linked Backbone Synthesis of HMIM dimer 10
3′-C
NC and CCN Linked Backbone Synthesis of Amine 1 and 2 Dimers (11 and 12)
2′-OMe 3′-C
NO Linked Backbone Synthesis of bis 2′-OMe MMI Linked dimer 13
Conclusion
References