Chapter 11. Nanoparticles for Cancer Drug Delivery

  1. Dr. Challa S. S. R. Kumar1,
  2. Prof. Dr. Josef Hormes1 and
  3. Prof. Dr. Carola Leuschner2
  1. Prof. Dr. Carola Leuschner2 and
  2. Dr. Challa S. S. R. Kumar1

Published Online: 12 APR 2005

DOI: 10.1002/3527603476.ch11

Nanofabrication Towards Biomedical Applications: Techniques, Tools, Applications, and Impact

Nanofabrication Towards Biomedical Applications: Techniques, Tools, Applications, and Impact

How to Cite

Leuschner, C. and Kumar, C. S. S. R. (2005) Nanoparticles for Cancer Drug Delivery, in Nanofabrication Towards Biomedical Applications: Techniques, Tools, Applications, and Impact (eds C. S. S. R. Kumar, J. Hormes and C. Leuschner), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603476.ch11

Editor Information

  1. 1

    Center for Advanced Microstructures and Devices, Louisiana State University, 6980 Jefferson Highway, Baton Rouge, LA 70806, USA

  2. 2

    Reproductive Biotechnology Laboratory, Pennington Biomedical Research Centre, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA

Author Information

  1. 1

    Center for Advanced Microstructures and Devices, Louisiana State University, 6980 Jefferson Highway, Baton Rouge, LA 70806, USA

  2. 2

    Reproductive Biotechnology Laboratory, Pennington Biomedical Research Centre, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA

Publication History

  1. Published Online: 12 APR 2005
  2. Published Print: 20 JAN 2005

ISBN Information

Print ISBN: 9783527311156

Online ISBN: 9783527603473

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Keywords:

  • nanotechnology;
  • biomedical applications;
  • nanoparticles for cancer drug delivery;
  • characteristics of tumor tissues;
  • physicochemical properties of nanoparticles in cancer therapy;
  • drug delivery to tumors;
  • nonviral gene therapy with nanoparticles;
  • hyperthermia

Summary

  • Introduction

  • Cancer: A Fatal Disease and Current Approaches to Its Cure

  • Characteristics of Tumor Tissues

  • Drug Delivery to Tumors

  • Physicochemical Properties of Nanoparticles in Cancer Therapy

    • In Vivo Circulation Pathways of Nanoparticles

    • Surface Treatment or Coating of Nanoparticles

    • Polymers for Encapsulation

  • Site-Specific Delivery of Chemotherapeutic Agents Using Nanoparticles

    • Passive Targeting

      • Targeting Lymph Nodes with Nanoparticles

      • Increasing Bioavailability of a Compound

    • Active Targeting

      • Magnetically Directed Targeting to Tumor Tissue

      • Ligand-Directed Active Targeting

      • Targeted Drug Delivery Using Magnetic Guidance

  • Nonviral Gene Therapy with Nanoparticles

  • Hyperthermia

  • Controlled Delivery of Chemotherapeutic Drugs Using Nanoparticles

  • Nanoparticles to Circumvent MDR

  • Potential Problems in Using Nanoparticles for Cancer Treatment

  • Future Outlook