Chapter 2. Fundamentals and General Terminology

  1. Prof. Dr.-Ing. Henner Schmidt-Traub
  1. Dr. M. Schulte1,
  2. Dr.-Ing. A. Epping2

Published Online: 12 APR 2005

DOI: 10.1002/3527603484.ch2

Book Title

Preparative Chromatography: of Fine Chemicals and Pharmaceutical Agents

Preparative Chromatography: of Fine Chemicals and Pharmaceutical Agents

Additional Information

How to Cite

Schulte, M. and Epping, A. (2005) Fundamentals and General Terminology, in Preparative Chromatography: of Fine Chemicals and Pharmaceutical Agents (ed H. Schmidt-Traub), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603484.ch2

Editor Information

  1. Universität Dortmund, Fachbereich Bio- und Chemieingenieurwesen, Lehrstuhl für Anlagentechnik, Emil-Figge-Str. 70, 44221 Dortmund, Germany

Author Information

  1. 1

    Merck KGaA, Life Science & Analytics R&D, Frankfurter Str. 250, 64293 Darmstadt, Germany

  2. 2

    BP Köln GmbH, Betriebstechnik, Postfach 75 02 12, 50754 Köln, Germany

Publication History

  1. Published Online: 12 APR 2005
  2. Published Print: 26 JAN 2005

ISBN Information

Print ISBN: 9783527306435

Online ISBN: 9783527603480

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Keywords:

  • preparative chromatography;
  • fundamentals and general terminology;
  • adsorption chromatography;
  • basic effects and chromatographic definitions;
  • fluid dynamics;
  • mass transfer phenomena;
  • equilibrium thermodynamics;
  • thermodynamic effects on mass separation;
  • practical aspects of parameter determination

Summary

This chapter contains sections titled:

  • Principles of Adsorption Chromatography

    • Adsorption Process

    • Chromatographic Process

  • Basic Effects and Chromatographic Definitions

    • Chromatograms and their Parameters

    • Voidage and Porosity

    • Influence of Adsorption Isotherms on the Chromatogram

  • Fluid Dynamics

    • Extra Column Effects

    • Column Fluid Distribution

    • Packing Non-idealities

    • Sources for Non-ideal Fluid Distribution

  • Mass Transfer Phenomena

    • Principles of Mass Transfer

    • Efficiency of Chromatographic Separations

    • Resolution

  • Equilibrium Thermodynamics

    • Definition of Isotherms

    • Models of Isotherms

      • Single-component Isotherms

      • Multi-component Isotherms

      • Ideal Adsorbed Solution (IAS) Theory

  • Thermodynamic Effects on Mass Separation

    • Mass Load

    • Linear and Nonlinear Isotherms

    • Elution Modes

  • Practical Aspects of Parameter Determination

    • Linearized Chromatography

    • Nonlinear Chromatography

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