Chapter 5. Process Concepts

  1. Prof. Dr.-Ing. Henner Schmidt-Traub
  1. Dr. M. Schulte1,
  2. Dipl.-Ing. K. Wekenborg2,
  3. Dipl.-Ing. W. Wewers2

Published Online: 12 APR 2005

DOI: 10.1002/3527603484.ch5

Book Title

Preparative Chromatography: of Fine Chemicals and Pharmaceutical Agents

Preparative Chromatography: of Fine Chemicals and Pharmaceutical Agents

Additional Information

How to Cite

Schulte, M., Wekenborg, K. and Wewers, W. (2005) Process Concepts, in Preparative Chromatography: of Fine Chemicals and Pharmaceutical Agents (ed H. Schmidt-Traub), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603484.ch5

Editor Information

  1. Universität Dortmund, Fachbereich Bio- und Chemieingenieurwesen, Lehrstuhl für Anlagentechnik, Emil-Figge-Str. 70, 44221 Dortmund, Germany

Author Information

  1. 1

    Merck KGaA, Life Science & Analytics R&D, Frankfurter Str. 250, 64293 Darmstadt, Germany

  2. 2

    University of Dortmund, Department of Biochemical and Chemical Engineering, Chair of Plant and Process Design, 44221 Dortmund, Germany

Publication History

  1. Published Online: 12 APR 2005
  2. Published Print: 26 JAN 2005

ISBN Information

Print ISBN: 9783527306435

Online ISBN: 9783527603480

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CHAPTER TOOLS

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Keywords:

  • preparative chromatography;
  • process concepts;
  • design and operation of equipment;
  • solvent and sample delivery system;
  • chromatographic column;
  • detection and separation system;
  • discontinuous processes;
  • continuous processes;
  • guidelines;
  • examples

Summary

This chapter contains sections titled:

  • Design and Operation of Equipment

    • Solvent and Sample Delivery System

      • HPLC Pumps

      • Gradient Formation

      • Eluent Degassing

      • Eluent Reservoir

      • Sample Injection

    • Chromatographic Column

    • Detection and Separation System

      • Solvent-sensitive Detectors

      • Fraction Collection

  • Discontinuous Processes

    • Isocratic Operation

    • Flip-flop Chromatography

    • Closed-loop Recycling Chromatography

    • Steady State Recycling Chromatography

    • Gradient Chromatography

  • Continuous Processes

    • Column Switching Chromatography

    • Annular Chromatography

    • Multiport Switching Valve Chromatography (ISEP/CSEP)

    • Simulated Moving Bed (SMB) Chromatography

    • SMB Chromatography with Variable Conditions

      • VariCol

      • PowerFeed

      • Partial feed

      • ISMB

      • ModiCon

    • Gradient SMB Chromatography

      • Solvent-gradient SMB Chromatography

      • Supercritical Fluid SMB Chromatography

      • Temperature-gradient SMB Chromatography

  • Guidelines

    • Scale

    • Range of k′

    • Number of Fractions

    • Example 1: Lab Scale; Two Fractions

    • Example 2: Lab Scale; Three or More Fractions

    • Example 3: Production Scale; Wide Range of k′

    • Example 4: Production Scale; Two Main Fractions

    • Example 5: Production Scale; Three Fractions

    • Example 6: Production Scale; Multi-stage Process

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