Chapter 7. Model Based Design and Optimization

  1. Prof. Dr.-Ing. Henner Schmidt-Traub
  1. Dipl.-Ing. A. Susanto1,
  2. Dipl.-Ing. K. Wekenborg1,
  3. Dr.-Ing. A. Epping2,
  4. Dr.-Ing. A. Jupke3

Published Online: 12 APR 2005

DOI: 10.1002/3527603484.ch7

Book Title

Preparative Chromatography: of Fine Chemicals and Pharmaceutical Agents

Preparative Chromatography: of Fine Chemicals and Pharmaceutical Agents

Additional Information

How to Cite

Susanto, A., Wekenborg, K., Epping, A. and Jupke, A. (2005) Model Based Design and Optimization, in Preparative Chromatography: of Fine Chemicals and Pharmaceutical Agents (ed H. Schmidt-Traub), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603484.ch7

Editor Information

  1. Universität Dortmund, Fachbereich Bio- und Chemieingenieurwesen, Lehrstuhl für Anlagentechnik, Emil-Figge-Str. 70, 44221 Dortmund, Germany

Author Information

  1. 1

    University of Dortmund, Department of Biochemical and Chemical Engineering, Chair of Plant and Process Design, 44221 Dortmund, Germany

  2. 2

    BP Köln GmbH, Betriebstechnik, Postfach 75 02 12, 50754 Köln, Germany

  3. 3

    Bayer Technology Services GmbH, Process Design, 51386 Leverkusen, Germany

Publication History

  1. Published Online: 12 APR 2005
  2. Published Print: 26 JAN 2005

ISBN Information

Print ISBN: 9783527306435

Online ISBN: 9783527603480

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CHAPTER TOOLS

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Keywords:

  • preparative chromatography;
  • model based design and optimization;
  • objective functions;
  • degrees of freedom;
  • scaling up and down;
  • batch chromatography;
  • fractionation mode (cut strategy);
  • SMB chromatography;
  • comparison of batch and SMB chromatography

Summary

This chapter contains sections titled:

  • Basic Principles

    • Objective Functions

      • Characterization of Process Performance

      • Total Separation Cost

    • Degrees of Freedom

      • Classification of Optimization Parameters

      • Dimensionless Representation of Operating and Design Parameters

    • Scaling Up and Down

      • Influence of Different HETP Coefficients for Every Component

      • Influence of Feed Concentration

      • Examples for a Single Batch Chromatographic Column

      • Examples for SMB Processes

  • Batch chromatography

    • Fractionation Mode (Cut Strategy)

    • Design and Optimization Strategy for Batch Chromatographic Column

    • Process Performance Depending on Number of Stages and Loading Factor

    • Design and Optimization Strategies from Other Authors

  • SMB Chromatography

    • Optimization of Operating Parameters

      • Process Design Based on TMB Models (Short-cut Methods)

      • Process Design Based on SMB Models

    • Optimization of Design Parameters

  • Comparison of Batch and SMB Chromatography

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