Chapter 10. Evolution and Self-Organization

  1. Dr. E. Klipp,
  2. Dr. R. Herwig,
  3. Dr. A. Kowald,
  4. C. Wierling,
  5. Prof. Dr. H. Lehrach

Published Online: 11 MAY 2005

DOI: 10.1002/3527603603.ch10

Book Title

Systems Biology in Practice: Concepts, Implementation and Application

Systems Biology in Practice: Concepts, Implementation and Application

Additional Information

How to Cite

Klipp, E., Herwig, R., Kowald, A., Wierling, C. and Lehrach, H. (2005) Evolution and Self-Organization, in Systems Biology in Practice: Concepts, Implementation and Application, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603603.ch10

Author Information

  1. MPI für Molekulare Genetik, Ihnestraße 73, 14195 Berlin, Germany

Publication History

  1. Published Online: 11 MAY 2005
  2. Published Print: 17 FEB 2005

ISBN Information

Print ISBN: 9783527310784

Online ISBN: 9783527603602

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Keywords:

  • evolution and self-organization;
  • quasispecies;
  • hypercycles;
  • self-replication;
  • biological macromolecules;
  • mathematical models of evolution;
  • prediction of biological systems from optimality principles;
  • single enzymes

Summary

This chapter contains sections titled:

  • Quasispecies and Hypercycles

    • Selection Equations for Biological Macromolecules

      • Self-replication Without Interaction

      • Selection at Constant Total Concentration of Self-replicating Molecules

      • Self-replication with Mutations: The Quasispecies Model

      • The Genetic Algorithm

      • Assessment of Sequence Length for Stable Passing-on of Sequence Information

      • Coexistence of Self-replicating Sequences: Complementary Replication of RNA

    • The Hypercycle

  • Other Mathematical Models of Evolution

    • Spin-glass Model of Evolution

    • Neutral Theory of Molecular Evolution

    • Boolean Network Models

  • Prediction of Biological Systems from Optimality Principles

    • Optimization of Catalytic Properties of Single Enzymes

    • Optimal Distribution of Enzyme Concentrations in a Metabolic Pathway

    • Temporal Transcription Programs

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