Chapter 8. Modeling of Gene Expression

  1. Dr. E. Klipp,
  2. Dr. R. Herwig,
  3. Dr. A. Kowald,
  4. C. Wierling,
  5. Prof. Dr. H. Lehrach

Published Online: 11 MAY 2005

DOI: 10.1002/3527603603.ch8

Book Title

Systems Biology in Practice: Concepts, Implementation and Application

Systems Biology in Practice: Concepts, Implementation and Application

Additional Information

How to Cite

Klipp, E., Herwig, R., Kowald, A., Wierling, C. and Lehrach, H. (2005) Modeling of Gene Expression, in Systems Biology in Practice: Concepts, Implementation and Application, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603603.ch8

Author Information

  1. MPI für Molekulare Genetik, Ihnestraße 73, 14195 Berlin, Germany

Publication History

  1. Published Online: 11 MAY 2005
  2. Published Print: 17 FEB 2005

ISBN Information

Print ISBN: 9783527310784

Online ISBN: 9783527603602

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Keywords:

  • modeling of gene expression;
  • modules of gene expression;
  • promoter identification;
  • modeling specific processes in eukaryotic gene expression;
  • Bayesian networks;
  • Boolean networks;
  • modeling the regulation of operons in E. coli

Summary

This chapter contains sections titled:

  • Modules of Gene Expression

  • Promoter Identification

    • General Promoter Structure

    • Sequence-based Prediction of Promoter Elements

    • Approaches that Incorporate Additional Information

  • Modeling Specific Processes in Eukaryotic Gene Expression

    • One Example, Different Approaches

      • Description with Ordinary Differential Equations

      • Representation of Gene Network as Directed and Undirected Graphs

      • Bayesian Networks

      • Boolean Networks

      • Gene Expression Modeling with Stochastic Equations

    • Time Delay in Gene Regulation

    • Modeling the Elongation of a Peptide Chain

  • Modeling the Regulation of Operons in E. coli

    • Mechanism of the Lac Operon in E. coli

    • The Model According to Griffith

    • The Model According to Nicolis and Prigogine

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