Chapter 1.2. Synthesis and Application of Proline and Pipecolic Acid Derivatives: Tools for Stabilization of Peptide Secondary Structures

  1. Professor Dr. Carsten Schmuck2 and
  2. Professor Dr. Helma Wennemers3
  1. Wolfgang Maison

Published Online: 27 MAY 2005

DOI: 10.1002/3527603727.ch1b

Highlights in Bioorganic Chemistry: Methods and Applications

Highlights in Bioorganic Chemistry: Methods and Applications

How to Cite

Maison, W. (2004) Synthesis and Application of Proline and Pipecolic Acid Derivatives: Tools for Stabilization of Peptide Secondary Structures, in Highlights in Bioorganic Chemistry: Methods and Applications (eds C. Schmuck and H. Wennemers), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603727.ch1b

Editor Information

  1. 2

    Institute of Organic Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany

  2. 3

    Department of Chemistry, University of Basel, St. Johanns Ring 19, CH-4056 Basel, Switzerland

Author Information

  1. Institut für Organische Chemie der Universität Hamburg, Martin-Luther-King-Platz 6, 20146 Hamburg, Germany

Publication History

  1. Published Online: 27 MAY 2005
  2. Published Print: 14 JAN 2004

ISBN Information

Print ISBN: 9783527306565

Online ISBN: 9783527603725

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Keywords:

  • biomolecules;
  • conformation;
  • stabilization of peptide secondary structures;
  • proline syn-anti isomerization;
  • coordination of metal ions

Summary

This chapter contains sections titled:

    • Introduction

    • syn- and anti-Proline Mimics

    • Templates for α-Helix Stabilization

    • References

    • Proline syn-anti Isomerization, Implications for Protein Folding