Chapter 2.5. Evaluation of the DNA-Binding Properties of Cationic Dyes by Absorption and Emission Spectroscopy

  1. Professor Dr. Carsten Schmuck2 and
  2. Professor Dr. Helma Wennemers3
  1. Heiko Ihmels2,
  2. Katja Faulhaber2,
  3. Giampietro Viola1 and
  4. Professor Dr. Carsten Schmuck2

Published Online: 27 MAY 2005

DOI: 10.1002/3527603727.ch2e

Highlights in Bioorganic Chemistry: Methods and Applications

Highlights in Bioorganic Chemistry: Methods and Applications

How to Cite

Ihmels, H., Faulhaber, K., Viola, G. and Schmuck, C. (2004) Evaluation of the DNA-Binding Properties of Cationic Dyes by Absorption and Emission Spectroscopy, in Highlights in Bioorganic Chemistry: Methods and Applications (eds C. Schmuck and H. Wennemers), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603727.ch2e

Editor Information

  1. 2

    Institute of Organic Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany

  2. 3

    Department of Chemistry, University of Basel, St. Johanns Ring 19, CH-4056 Basel, Switzerland

Author Information

  1. 1

    Department of Pharmaceutical Sciences, University of Padova Via Marzolo 5, 35131 Padova, Italy

  2. 2

    Institute of Organic Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany

Publication History

  1. Published Online: 27 MAY 2005
  2. Published Print: 14 JAN 2004

ISBN Information

Print ISBN: 9783527306565

Online ISBN: 9783527603725

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Keywords:

  • non-covalent intermolecular interactions;
  • DNA-binding properties;
  • binding of small molecules to DNA

Summary

This chapter contains sections titled:

    • Introduction

    • Binding Modes

      • Groove Binding

      • Intercalation

    • Evaluation of the Binding

      • UV—Visible Spectroscopy

      • Emission Spectroscopy

      • CD Spectroscopy

      • LD Spectroscopy

    • Acknowledgment

    • References

    • Binding of Small Molecules to DNA — Groove Binding and Intercalation