Chapter 3.4. Enantiomeric Nucleic Acids — Spiegelmers

  1. Professor Dr. Carsten Schmuck2 and
  2. Professor Dr. Helma Wennemers3
  1. Sven Klussmann

Published Online: 27 MAY 2005

DOI: 10.1002/3527603727.ch3d

Highlights in Bioorganic Chemistry: Methods and Applications

Highlights in Bioorganic Chemistry: Methods and Applications

How to Cite

Klussmann, S. (2004) Enantiomeric Nucleic Acids — Spiegelmers, in Highlights in Bioorganic Chemistry: Methods and Applications (eds C. Schmuck and H. Wennemers), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603727.ch3d

Editor Information

  1. 2

    Institute of Organic Chemistry, University of Würzburg, Am Hubland, 97074 Würzburg, Germany

  2. 3

    Department of Chemistry, University of Basel, St. Johanns Ring 19, CH-4056 Basel, Switzerland

Author Information

  1. NOXXON Pharma AG, Max-Dohrn-Straße 8-10, 10589 Berlin, Germany

Publication History

  1. Published Online: 27 MAY 2005
  2. Published Print: 14 JAN 2004

ISBN Information

Print ISBN: 9783527306565

Online ISBN: 9783527603725

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Keywords:

  • studies in drug developments;
  • enantiomeric nucleic acids

Summary

This chapter contains sections titled:

    • Towards Nucleic Acid Shape Libraries

    • In-vitro Selection or SELEX Technology

    • Aspects of Chirality

    • Spiegelmer Technology

    • Examples and Properties of Mirror-image Oligonucleotides

      • Spiegelmers Binding to Small Molecules

      • Mirror-image DNA Inhibiting Vasopressin in Cell Culture

      • RNA and DNA Spiegelmers Binding to GnRH

      • In-vivo Data of GnRH Binding Spiegelmers

    • Conclusion

    • Acknowledgments

    • Appendix

    • References