Chapter 11. Centrosome Regulation in Response to Environmental and Genotoxic Stress

  1. Prof. Dr. Erich A. Nigg
  1. Ody C. M. Sibon1 and
  2. William E. Theurkauf2

Published Online: 17 JUN 2005

DOI: 10.1002/3527603808.ch11

Centrosomes in Development and Disease

Centrosomes in Development and Disease

How to Cite

Sibon, O. C. M. and Theurkauf, W. E. (2004) Centrosome Regulation in Response to Environmental and Genotoxic Stress, in Centrosomes in Development and Disease (ed E. A. Nigg), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603808.ch11

Editor Information

  1. Max-Planck-Institute of Biochemistry, Department of Cell Biology, Am Klopferspitz 18a, 82152 Martinsried, Germany

Author Information

  1. 1

    Department of Radiation and Stress Cell Biology, University of Groningen, Ant. Deusinglaan 1, 9713 AV Groningen, The Netherlands

  2. 2

    Program in Cell Dynamics and Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Worcester, MA 01605, USA

Publication History

  1. Published Online: 17 JUN 2005
  2. Published Print: 27 JUL 2004

ISBN Information

Print ISBN: 9783527309801

Online ISBN: 9783527603800

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Keywords:

  • centrosomes in development;
  • centrosomes in disease;
  • centrosome regulation;
  • environmental stress;
  • genotoxic stress;
  • heat shock;
  • protein response;
  • centrosome disruption;
  • centrosome inactivation;
  • Chk2;
  • DNA damage;
  • mitotic catastrophe;
  • mitosis;
  • mammalian cells

Summary

This chapter contains sections titled:

  • Introduction

  • Heat Shock

  • Centrosomes and the Unfolded Protein Response

  • Centrosome Disruption in Response to Genotoxic Stress

    • Centrosome Inactivation in Early Embryos

    • Chk2 is Required for DNA Damage-induced Mitotic Catastrophe

    • DNA Damage and Mitosis in Mammalian Cells

  • Final Thoughts

  • References