Chapter 13. Centrosomes in a Developing Organism: Lessons from Drosophila

  1. Prof. Dr. Erich A. Nigg
  1. Jordan W. Raff

Published Online: 17 JUN 2005

DOI: 10.1002/3527603808.ch13

Centrosomes in Development and Disease

Centrosomes in Development and Disease

How to Cite

Raff, J. W. (2004) Centrosomes in a Developing Organism: Lessons from Drosophila, in Centrosomes in Development and Disease (ed E. A. Nigg), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603808.ch13

Editor Information

  1. Max-Planck-Institute of Biochemistry, Department of Cell Biology, Am Klopferspitz 18a, 82152 Martinsried, Germany

Author Information

  1. Wellcome/CR UK Institute of Cancer and Developmental Biology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK

Publication History

  1. Published Online: 17 JUN 2005
  2. Published Print: 27 JUL 2004

ISBN Information

Print ISBN: 9783527309801

Online ISBN: 9783527603800

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Keywords:

  • centrosomes in development;
  • centrosomes in disease;
  • centrosome;
  • developing organism;
  • Drosophila;
  • oogenesis;
  • spermatogenesis;
  • embryogenesis;
  • embryonic neuroblasts;
  • larval development;
  • microtubule nucleation;
  • γ-tubulin;
  • γ-TuRC;
  • Asp;
  • Polo;
  • centrosomin (CNN);
  • Aurora A;
  • CP309/D-PLP;
  • D-TACC;
  • Msps;
  • actin cytoskeleton;
  • myosin cytoskeleton;
  • Scrambled;
  • Nuf;
  • CP190;
  • asl

Summary

This chapter contains sections titled:

  • Introduction

  • Centrosome and Microtubule Organisation during the Drosophila Life Cycle

    • Oogenesis

    • Spermatogenesis

    • Early Embryogenesis

    • Asymmetric Divisions of Embryonic Neuroblasts

    • Larval Development

  • Drosophila Centrosomal Proteins

    • Microtubule Nucleation from Centrosomes: γ-Tubulin and the γ-TuRC

    • The Recruitment of the γ-TuRC to Centrosomes: The Potential Roles of Asp, Polo, CNN, Aurora A, and CP309/D-PLP

    • The Interaction between Centrosomes and Microtubules: The Role of D-TACC and Msps

    • Centrosomes and the Organization of the Actin/Myosin Cytoskeleton in Early Fly Embryos: The Role of Scrambled, Nuf, and CP190

    • Centrosomes and Cytokinesis: Studies on asl, cnn, and γ-Tubulin Mutant Spermatocytes

    • Centrosomes and the Cell Cycle

    • Centrosome Dynamics: Inactivation and Flares

    • Microtubule Motors and Plus-end Tracking Proteins at the Centrosome

    • The Interphase Centrosome in Flies: Missing in Action?

  • The Role of Centrosomes and Centrosomal Proteins In Vivo

    • The Essential Role of Centrosomes in Drosophila

    • The Role of Centrosomal Proteins in Oogenesis

  • Summary

  • Acknowledgments

  • References