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Chapter 14. Centrosome Inheritance during Human Fertilization and “Therapeutic” Cloning: Reproductive and Developmental Diseases and Disorders Caused by Centrosome Dysfunction

  1. Prof. Dr. Erich A. Nigg
  1. C. S. Navara1,
  2. C. Simerly1,
  3. G. Schatten2

Published Online: 17 JUN 2005

DOI: 10.1002/3527603808.ch14

Book Title

Centrosomes in Development and Disease

Centrosomes in Development and Disease

Additional Information

How to Cite

Navara, C. S., Simerly, C. and Schatten, G. (2005) Centrosome Inheritance during Human Fertilization and “Therapeutic” Cloning: Reproductive and Developmental Diseases and Disorders Caused by Centrosome Dysfunction, in Centrosomes in Development and Disease (ed E. A. Nigg), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603808.ch14

Editor Information

  1. Max-Planck-Institute of Biochemistry, Department of Cell Biology, Am Klopferspitz 18a, 82152 Martinsried, Germany

Author Information

  1. 1

    Departments of Obstetrics, Gynecology and Reproductive Sciences, Pittsburgh Development Center and University of Pittsburgh, 204 Craft Avenue, Pittsburgh, PA 15213, USA

  2. 2

    Pittsburgh Development Center, Magee Womens Research Institute, University of Pittsburgh School of Medicine, Departments of Obstetrics, Gynecology and Reproductive Sciences, 204 Craft Avenue, Pittsburgh, PA 15213, USA

Publication History

  1. Published Online: 17 JUN 2005
  2. Published Print: 27 JUL 2004

ISBN Information

Print ISBN: 9783527309801

Online ISBN: 9783527603800

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CHAPTER TOOLS

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Keywords:

  • centrosomes in development;
  • centrosomes in disease;
  • centrosome inheritance;
  • human fertilization;
  • cloning;
  • diseases and disorders caused by centrosome dysfunction;
  • centrosome dysfunction;
  • human infertility;
  • male infertility;
  • polyspermy in humans;
  • genomic imprinted disorders;
  • maternal centrosome anomalies;
  • birth defects;
  • parthenogenesis;
  • cytoplasmic motors;
  • NuMA;
  • embryonic stem cells;
  • developmental centrosomopathies

Summary

This chapter contains sections titled:

  • Introduction

  • Centrosomes during Human Fertilization

  • Centrosome Dysfunction as Causes of Human Infertility

  • Centrosome Functional Assays for Diagnosing Male Infertility

  • Polyspermy in Humans

  • “Dispermy Hypothesis” for the Origins of Genomic Imprinted Disorders

  • Maternal Centrosome Anomalies and Birth Defects

  • Resolving the Special Problem of Parthenogenesis: Roles of Cytoplasmic Motors and NuMA

  • Centrosomes during Cloning, and Centrosomes in Embryonic Stem Cells Derived after Nuclear Transfer

  • Research Challenges for Centrosome Developmental Biologists: Developmental Centrosomopathies

  • References

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