Chapter 16. Centrosome Anomalies in Cancer: From Early Observations to Animal Models

  1. Prof. Dr. Erich A. Nigg
  1. Thea M. Goepfert1 and
  2. William R. Brinkley2

Published Online: 17 JUN 2005

DOI: 10.1002/3527603808.ch16

Centrosomes in Development and Disease

Centrosomes in Development and Disease

How to Cite

Goepfert, T. M. and Brinkley, W. R. (2004) Centrosome Anomalies in Cancer: From Early Observations to Animal Models, in Centrosomes in Development and Disease (ed E. A. Nigg), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603808.ch16

Editor Information

  1. Max-Planck-Institute of Biochemistry, Department of Cell Biology, Am Klopferspitz 18a, 82152 Martinsried, Germany

Author Information

  1. 1

    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza-117AA, Houston, TX 77030, USA

  2. 2

    Graduate School of Biomedical Sciences, Baylor College of Medicine, One Baylor Plaza-N204, Houston, TX 77030, USA

Publication History

  1. Published Online: 17 JUN 2005
  2. Published Print: 27 JUL 2004

ISBN Information

Print ISBN: 9783527309801

Online ISBN: 9783527603800

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Keywords:

  • centrosomes in development;
  • centrosomes in disease;
  • centrosome anomalies;
  • cancer;
  • deregulation of centrosome duplication;
  • de novo formation of centrioles;
  • uncontrolled separation of centriole pairs;
  • cytokinesis;
  • p53 pathway;
  • BRCA 1;
  • Aurora A

Summary

This chapter contains sections titled:

  • Early Observations

  • Origin of Centrosome Anomalies

    • Deregulation of Centrosome Duplication

    • De Novo Formation of Centrioles or Uncontrolled Separation of Centriole Pairs

    • Failure to Undergo Cytokinesis

    • Fusion of Cells

  • Animal Models

    • Centrosome Anomalies and the p53 Pathway

    • Centrosome Anomalies and BRCA 1

    • Centrosome Anomalies and Aurora A

  • Acknowledgments

  • References