Chapter 18. Human Papillomavirus Infection and Centrosome Anomalies in Cervical Cancer

  1. Prof. Dr. Erich A. Nigg
  1. Karl Münger1 and
  2. Stefan Duensing2

Published Online: 17 JUN 2005

DOI: 10.1002/3527603808.ch18

Centrosomes in Development and Disease

Centrosomes in Development and Disease

How to Cite

Münger, K. and Duensing, S. (2005) Human Papillomavirus Infection and Centrosome Anomalies in Cervical Cancer, in Centrosomes in Development and Disease (ed E. A. Nigg), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603808.ch18

Editor Information

  1. Max-Planck-Institute of Biochemistry, Department of Cell Biology, Am Klopferspitz 18a, 82152 Martinsried, Germany

Author Information

  1. 1

    Pathology Department, Harvard Medical School, 77 Avenue Louis Pasteur, NRB, Room 0958c, Boston, MA 02115-5727, USA

  2. 2

    Molecular Virology Program, University of Pittsburgh Cancer Institute, Hillman Cancer Center, Research Pavilion Suite 1– 8, 5117 Centre Avenue, Pittsburgh, PA 15213, USA

Publication History

  1. Published Online: 17 JUN 2005
  2. Published Print: 27 JUL 2004

ISBN Information

Print ISBN: 9783527309801

Online ISBN: 9783527603800

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Keywords:

  • centrosomes in development;
  • centrosomes in disease;
  • papillomavirus infection;
  • centrosome anomalies;
  • cervical cancer;
  • genomic instability;
  • malignant progression;
  • human papilloma viruses;
  • HPV E6/E7;
  • HPV-mediated cervical carcinogenesis;
  • HPV oncoproteins;
  • Boveris model;
  • carcinogenic progression

Summary

This chapter contains sections titled:

  • Genomic Instability and Malignant Progression

  • Human Papilloma viruses

  • Biological Activities of HPV E6/E7 Oncogenes

  • HPV-mediated Cervical Carcinogenesis as a Model System to Study Genomic Instability and Malignant Progression

  • Centrosome Abnormalities and Genomic Instability: Cause or Effect?

  • Induction of Centrosome Abnormalities by HPV Oncoproteins: Boveris Model Revisited

  • Do HPV E7-induced Centrosome Anomalies Contribute to Carcinogenic Progression?

  • Mechanistic Considerations

  • Concluding Remarks

  • Acknowledgments

  • References