Chapter 3. Microtubule Nucleation

  1. Prof. Dr. Erich A. Nigg
  1. Michelle Moritz,
  2. Luke M. Rice and
  3. David A. Agard

Published Online: 17 JUN 2005

DOI: 10.1002/3527603808.ch3

Centrosomes in Development and Disease

Centrosomes in Development and Disease

How to Cite

Moritz, M., Rice, L. M. and Agard, D. A. (2004) Microtubule Nucleation, in Centrosomes in Development and Disease (ed E. A. Nigg), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603808.ch3

Editor Information

  1. Max-Planck-Institute of Biochemistry, Department of Cell Biology, Am Klopferspitz 18a, 82152 Martinsried, Germany

Author Information

  1. Department of Biochemistry & Biophysics, University of California, San Francisco, 600 16th Street, San Francisco, CA 94143-2240, USA

Publication History

  1. Published Online: 17 JUN 2005
  2. Published Print: 27 JUL 2004

ISBN Information

Print ISBN: 9783527309801

Online ISBN: 9783527603800



  • centrosomes in development;
  • centrosomes in disease;
  • microtubule nucleation;
  • γ-tubulin;
  • γ-TuRC/Tub4 complex


This chapter contains sections titled:

  • Introduction

    • The Nucleation of Microtubules can occur Spontaneously In Vitro, but Requires γ-Tubulin In Vivo

    • Models for the Mechanism of γ-TuRC/Tub4 Complex-mediated Microtubule Nucleation

  • Kinetic Models of the Mechanism of Microtubule Nucleation

  • The Involvement of Non-γ-TuRC Proteins in Microtubule Nucleation

  • Future Directions

  • Acknowledgments

  • References