Chapter 6. The Centrosome in Evolution

  1. Prof. Dr. Erich A. Nigg
  1. Juliette Azimzadeh and
  2. Michel Bornens

Published Online: 17 JUN 2005

DOI: 10.1002/3527603808.ch6

Centrosomes in Development and Disease

Centrosomes in Development and Disease

How to Cite

Azimzadeh, J. and Bornens, M. (2004) The Centrosome in Evolution, in Centrosomes in Development and Disease (ed E. A. Nigg), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603808.ch6

Editor Information

  1. Max-Planck-Institute of Biochemistry, Department of Cell Biology, Am Klopferspitz 18a, 82152 Martinsried, Germany

Author Information

  1. Institut Curie, UMR 144-CNRS, 26, rue d'Ulm, 75248 Paris Cedex 05, France

Publication History

  1. Published Online: 17 JUN 2005
  2. Published Print: 27 JUL 2004

ISBN Information

Print ISBN: 9783527309801

Online ISBN: 9783527603800



  • centrosomes in development;
  • centrosomes in disease;
  • evolution;
  • centriole body structure;
  • basal body structure;
  • eukaryotes;
  • ancestral structure;
  • flagellar apparatus;
  • cell locomotion;
  • sensory reception;
  • cell division;
  • duplication of basal body;
  • duplication of centriole;
  • duplication of SPB;
  • cell morphogenesis;
  • centrosome;
  • γ-tubulin;
  • centrin;
  • cell center


This chapter contains sections titled:

  • Introduction

  • The Centriole/Basal Body Structure is a Derived Characteristic of Eukaryotes

  • The Basal Body/Axoneme is the Ancestral Structure

  • Functions Associated with the Flagellar Apparatus

    • Cell Locomotion

    • Sensory Reception

    • Cell Division

  • The Conservative Mode of Duplication of the Basal Body/Centriole/SPB: An Essential Clue for Cell Morphogenesis

  • The Centrosome or Central Body

  • Evolution of Centrosome-associated Gene Products

    • γ-Tubulin

    • Centrin

    • Centrin-binding Proteins

  • Conclusion: The Centrosome – A Cell Individuation Organ?

    • Survival Value of Coupling Basic Functional Modules on the Same Organ

    • Co-Evolution of the Centrosome and the Cleavage Apparatus

    • The Biological Significance of Having a Cell Center

  • Acknowledgments

  • References