Chapter 9. Centrosome Duplication and its Regulation in the Higher Animal Cell

  1. Prof. Dr. Erich A. Nigg
  1. Greenfield Sluder

Published Online: 17 JUN 2005

DOI: 10.1002/3527603808.ch9

Centrosomes in Development and Disease

Centrosomes in Development and Disease

How to Cite

Sluder, G. (2004) Centrosome Duplication and its Regulation in the Higher Animal Cell, in Centrosomes in Development and Disease (ed E. A. Nigg), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603808.ch9

Editor Information

  1. Max-Planck-Institute of Biochemistry, Department of Cell Biology, Am Klopferspitz 18a, 82152 Martinsried, Germany

Author Information

  1. Department of Cell Biology, University of Massachusetts Medical School, 377 Plantation Street, Worcester, MA 01605, USA

Publication History

  1. Published Online: 17 JUN 2005
  2. Published Print: 27 JUL 2004

ISBN Information

Print ISBN: 9783527309801

Online ISBN: 9783527603800

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Keywords:

  • centrosomes in development;
  • centrosomes in disease;
  • centrosome duplication;
  • centrosome reproduction;
  • centriole disorientation;
  • centriole duplication;
  • centrosome disjunction;
  • centrosome separation;
  • kinase;
  • zygote systems;
  • mammalian somatic cells;
  • Cdk2–cyclin E kinase;
  • ubiquitin

Summary

This chapter contains sections titled:

  • Introduction

  • The Events of Centrosome Reproduction

    • Centriole Disorientation

    • Centriole Duplication

    • Centrosome Disjunction

    • Centrosome Separation

    • Some Proteins Needed for Centrosome Reproduction

  • Control of Centrosome Duplication

    • Control of Centrosome Number: Intrinsic Mechanisms

    • Block to Re-replication

    • Time of Centrosome Duplication: Extrinsic Controls

    • Cyclin-dependent Kinases in the Control of Centrosome Reproduction

      • Zygote Systems

      • Mammalian Somatic Cells

    • Targets of Cdk2–Cyclin E Kinase

    • Other Kinases Involved in Centrosome Duplication

    • Ubiquitin-mediated Proteolysis in the Control of Centrosome Duplication

  • Closing Remarks

  • Acknowledgments

  • References