Chapter 1. Stroke

  1. Prof. Dr. Mathias Bähr
  1. Andreas Meisel,
  2. Konstantin Prass,
  3. Tilo Wolf and
  4. Ulrich Dirnagl

Published Online: 17 JUN 2005

DOI: 10.1002/3527603867.ch1

Neuroprotection: Models, Mechanisms and Therapies

Neuroprotection: Models, Mechanisms and Therapies

How to Cite

Meisel, A., Prass, K., Wolf, T. and Dirnagl, U. (2004) Stroke, in Neuroprotection: Models, Mechanisms and Therapies (ed M. Bähr), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603867.ch1

Editor Information

  1. Department of Neurology, University of Göttingen Medical School, Robert-Koch-Str. 40, 37075 Göttingen, Germany

Author Information

  1. Department of Neurology, Humboldt-University Berlin, Schumannstr. 20–21, D-10098 Berlin, Germany

Publication History

  1. Published Online: 17 JUN 2005
  2. Published Print: 27 JUL 2004

ISBN Information

Print ISBN: 9783527308163

Online ISBN: 9783527603862

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Keywords:

  • neuroprotection models;
  • mechanisms and therapies;
  • neurological disorders – epidemiology;
  • clinical overview;
  • model systems;
  • stroke;
  • the penumbra concept;
  • excitotoxicity;
  • oxygen free radicals;
  • tissue acidosis;
  • peri-infarct depolarizations;
  • inflammation;
  • damage to the blood–brain-barrier;
  • programmed cell death and apoptosis;
  • ischemia-induced DNA damage;
  • DNA repair;
  • p53 as genotoxic sensor;
  • epigenetics;
  • gene expression;
  • cell replacement;
  • endogenous neuroprotection – ischemic tolerance;
  • stroke induced immune depression (SIDS)

Summary

This chapter contains sections titled:

  • Introduction

  • The Penumbra Concept

  • Excitotoxicity

  • Oxygen Free Radicals

  • Tissue Acidosis

  • Peri-infarct Depolarizations

  • Inflammation

  • Damage to the Blood–Brain-Barrier

  • Programmed Cell Death and Apoptosis

  • Ischemia-induced DNA Damage, DNA Repair, and p53 as Genotoxic Sensor

  • Epigenetics

  • Gene Expression

  • Cell Replacement

  • Endogenous Neuroprotection – Ischemic Tolerance

  • Stroke Induced Immune Depression (SIDS)

  • Conclusion

  • References