Chapter 11. Protein Misfolding

  1. Prof. Dr. Mathias Bähr
  1. Milene Russelakis-Carneiro1,
  2. Claudio Hetz2,3,
  3. Joaquin Castilla2 and
  4. Claudio Soto Director Protein Misfolding4

Published Online: 17 JUN 2005

DOI: 10.1002/3527603867.ch11

Neuroprotection: Models, Mechanisms and Therapies

Neuroprotection: Models, Mechanisms and Therapies

How to Cite

Russelakis-Carneiro, M., Hetz, C., Castilla, J. and Soto, C. (2004) Protein Misfolding, in Neuroprotection: Models, Mechanisms and Therapies (ed M. Bähr), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603867.ch11

Editor Information

  1. Department of Neurology, University of Göttingen Medical School, Robert-Koch-Str. 40, 37075 Göttingen, Germany

Author Information

  1. 1

    Apoxis Inc., 18–20 Avenue de Sévelin, CH-1004 Lausanne, Switzerland

  2. 2

    University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA

  3. 3

    Instituto de Ciencias Biomédicas, Universidad de Chile, Santiago, Chile

  4. 4

    Disorders Lab, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA

Publication History

  1. Published Online: 17 JUN 2005
  2. Published Print: 27 JUL 2004

ISBN Information

Print ISBN: 9783527308163

Online ISBN: 9783527603862

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Keywords:

  • neuroprotection models;
  • mechanisms and therapies;
  • cellular and molecular mechanisms;
  • protein misfolding;
  • disease propagation by replication of prion protein misfolding;
  • prion biology;
  • prion pathogenesis;
  • neuronal targeting;
  • nuronal apoptosis in prion diseases;
  • ER-stress and apoptosis in prion diseases

Summary

This chapter contains sections titled:

  • Introduction

  • Disease Propagation by Replication of Prion Protein Misfolding

  • Prion Biology

  • Prion Pathogenesis

  • Neuronal Targeting

  • Neuronal Apoptosis in Prion Diseases

  • ER-Stress and Apoptosis in Prion Diseases

  • Concluding Remarks

  • References