Chapter 12. Axonal Growth Inhibition

  1. Prof. Dr. Mathias Bähr
  1. Anne D. Zurn1 and
  2. Christine E. Bandtlow2

Published Online: 17 JUN 2005

DOI: 10.1002/3527603867.ch12

Neuroprotection: Models, Mechanisms and Therapies

Neuroprotection: Models, Mechanisms and Therapies

How to Cite

Zurn, A. D. and Bandtlow, C. E. (2004) Axonal Growth Inhibition, in Neuroprotection: Models, Mechanisms and Therapies (ed M. Bähr), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603867.ch12

Editor Information

  1. Department of Neurology, University of Göttingen Medical School, Robert-Koch-Str. 40, 37075 Göttingen, Germany

Author Information

  1. 1

    Department of Experimental Surgery, Lausanne University Hospital, CH-1011 Lausanne, Switzerland

  2. 2

    Dept. of Neurobiochemistry, Institute of Medical Chemistry and Biochemistry, Fritz-Pregal-Str. 3, University of Innsbruck, A-6020 Innsbruck, Austria

Publication History

  1. Published Online: 17 JUN 2005
  2. Published Print: 27 JUL 2004

ISBN Information

Print ISBN: 9783527308163

Online ISBN: 9783527603862

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Keywords:

  • neuroprotection models;
  • mechanisms and therapies;
  • cellular and molecular mechanisms;
  • axonal growth inhibition;
  • intrinsic properties of CNS neurons;
  • CNS as a non-conducive growth environment;
  • cellular components of inhibition;
  • experimental strategies to overcome growth inhibition

Summary

This chapter contains sections titled:

  • Introduction

  • Intrinsic Properties of CNS Neurons

    • Survival of Injured Neurons

    • Developmental Loss Of Regenerative Ability

    • Intrinsic Differences in Growth Potential

    • Transient Expression of Growth-associated Molecules

    • Conditioning Lesion

  • Extrinsic Factors: The CNS as A Non-conducive Growth Environment

    • Cellular Components of Inhibition

      • The Glial Scar

      • Oligodendrocytes and Myelin (Wallerian Degeneration)

      • Secondary Injury: Inflammation, Cell-mediated Immunity, and Glial Cell Loss

      • Genetic Influences on Cellular Reactions to CNS Injury

    • Molecular Components of Inhibition

      • Axon growth Inhibitors in the Glial Scar

      • Myelin-associated Growth Inhibitors

    • Transduction of Axon Growth-inhibitory Signals

      • Receptors for Myelin-associated Inhibitors

      • Signaling Pathways of Myelin-associated Inhibitors

  • Experimental Strategies to Overcome Growth Inhibition

  • Conclusion

  • References