Chapter 13. Neurogenesis

  1. Prof. Dr. Mathias Bähr
  1. Sebastian Jessberger1 and
  2. Gerd Kempermann2

Published Online: 17 JUN 2005

DOI: 10.1002/3527603867.ch13

Neuroprotection: Models, Mechanisms and Therapies

Neuroprotection: Models, Mechanisms and Therapies

How to Cite

Jessberger, S. and Kempermann, G. (2004) Neurogenesis, in Neuroprotection: Models, Mechanisms and Therapies (ed M. Bähr), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603867.ch13

Editor Information

  1. Department of Neurology, University of Göttingen Medical School, Robert-Koch-Str. 40, 37075 Göttingen, Germany

Author Information

  1. 1

    The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd., La Jolla, CA 92037, USA

  2. 2

    Research Group “Neuronal Stem Cells”, Max Delbrück Centre for Molecular Medicine (MDC) Berlin-Buch, Robert-Rössle-Str. 10, D-13125 Berlin, Germany

Publication History

  1. Published Online: 17 JUN 2005
  2. Published Print: 27 JUL 2004

ISBN Information

Print ISBN: 9783527308163

Online ISBN: 9783527603862



  • neuroprotection models;
  • mechanisms and therapies;
  • cellular and molecular mechanisms;
  • neurogenesis;
  • neural stem- and precursor cells in the adult brain;
  • maturation and migration of adult-generated neurons in the adult brain;
  • age dependency;
  • regulation of adult neurogenesis;
  • possible functional relevance of neurogenesis in the adult brain;
  • therapeutic strategies for neural cell replacement


This chapter contains sections titled:

  • Introduction

  • Neural Stem- and Precursor Cells in the Adult Brain

    • Neural Stem Cells in the Adult Brain: In Vitro

    • Neural Stem Cells In The Adult Brain: In Vivo

  • Maturation and Migration of Adult-generated Neurons in the Adult Brain

  • Neurogenesis in the Adult Brain – Age Dependency, Persistence and Genetic Determinants

    • Neurogenesis in Aged Animals

    • Long-term Persistence of Adult-generated Neurons in the SVZ and Hippocampus

    • Genetic Influence on Adult Hippocampal Neurogenesis

  • Regulation of Adult Neurogenesis

    • Learning

    • Environmental Enrichment

    • Physical Activity

    • Stress and Depression

    • Epilepsy

    • Ischemia and Cortical Trauma

  • Possible Functional Relevance of Neurogenesis in the Adult Brain

  • Therapeutic Strategies for Neural Cell Replacement

    • Endogenous Neurogenesis

    • Transplantation of Stem- or Precursor Cells into the Damaged Brain

  • Acknowledgements

  • References