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Chapter 14. Excitotoxicity

  1. Prof. Dr. Mathias Bähr
  1. Stuart A. Lipton MD, PhD

Published Online: 17 JUN 2005

DOI: 10.1002/3527603867.ch14

Book Title

Neuroprotection: Models, Mechanisms and Therapies

Neuroprotection: Models, Mechanisms and Therapies

Additional Information

How to Cite

Lipton, S. A. (2005) Excitotoxicity, in Neuroprotection: Models, Mechanisms and Therapies (ed M. Bähr), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603867.ch14

Editor Information

  1. Department of Neurology, University of Göttingen Medical School, Robert-Koch-Str. 40, 37075 Göttingen, Germany

Author Information

  1. The Burnham Institute, The Salk institute for Biological Studies, The Scripps Research Institute, and the University of California, San Diego, La Jolla, California 92037, USA

Publication History

  1. Published Online: 17 JUN 2005
  2. Published Print: 27 JUL 2004

ISBN Information

Print ISBN: 9783527308163

Online ISBN: 9783527603862

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CHAPTER TOOLS

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Keywords:

  • neuroprotection models;
  • mechanisms and therapies;
  • cellular and molecular mechanisms;
  • excitotoxicity;
  • search for clinically-tolerated NMDA receptor antagonists;
  • memantine;
  • nitromemantines

Summary

This chapter contains sections titled:

  • Introduction

  • The Search for Clinically-Tolerated NMDA Receptor Antagonists

  • Excitotoxicity

    • Definition and Clinical Relevance

    • Links between Stroke and Vascular Dementia to Excitotoxic Damage

      • Possible Links between Excitotoxic Damage and Alzheimer's Disease

    • Pathophysiology of Excitotoxicity: Role of the NMDA Receptor

      • The Importance of Off-Rate from Channel Block

  • Memantine

    • Background and Pharmacology: Uncompetitive Open-channel Block

    • Voltage Dependence, Partial Trapping, and Other Possible Effects of Memantine

    • Neuroprotective Efficacy

  • NitroMemantines

  • Summary

  • Acknowledgments

  • Appendix

  • References

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