Chapter 16. Neurodegeneration

  1. Prof. Dr. Mathias Bähr
  1. Jörg B. Schulz MD

Published Online: 17 JUN 2005

DOI: 10.1002/3527603867.ch16

Neuroprotection: Models, Mechanisms and Therapies

Neuroprotection: Models, Mechanisms and Therapies

How to Cite

Schulz, J. B. (2004) Neurodegeneration, in Neuroprotection: Models, Mechanisms and Therapies (ed M. Bähr), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603867.ch16

Editor Information

  1. Department of Neurology, University of Göttingen Medical School, Robert-Koch-Str. 40, 37075 Göttingen, Germany

Author Information

  1. Department of General Neurology, Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tübingen, Hoppe-Seyler-Str. 3, D-72076 Tübingen, Germany

Publication History

  1. Published Online: 17 JUN 2005
  2. Published Print: 27 JUL 2004

ISBN Information

Print ISBN: 9783527308163

Online ISBN: 9783527603862

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Keywords:

  • neuroprotection models;
  • mechanisms and therapies;
  • neurodegeneration;
  • neuroprotection;
  • Wilson's Disease;
  • Parkinson's Disease;
  • Multiple System Atrophy and Progressive Supranuclear Palsy;
  • Alzheimer's Disease;
  • Huntington's Disease;
  • many clinical studies fail

Summary

This chapter contains sections titled:

  • What Is Neuroprotection?

  • Outcome Measures in Clinical Studies

  • Specific Diseases

    • Wilson's Disease

    • Parkinson's Disease

      • DATATOP Study

      • Dopamine Agonists

      • Anti-Excitotoxic Treatment

      • Neurotrophins

      • MAP Kinase Inhibitors

      • Transplantation

      • Deep Brain Stimulation

      • Coenzyme Q10

    • Multiple System Atrophy and Progressive Supranuclear Palsy

    • Alzheimer's Disease

      • Symptomatic Treatment

      • Antioxidants

      • Anti-inflammatory Approaches

      • Estrogen Replacement

      • NMDA Receptor Antagonists

      • Experimental Therapies

      • Immunization

      • Cholesterol-lowering Therapy

    • Huntington's Disease

  • Why Do So Many Clinical Studies Fail? What Do We Need?

  • References