Chapter 2. Parkinson's Disease

  1. Prof. Dr. Mathias Bähr
  1. Marina Romero-Ramos,
  2. Matthew Maingay and
  3. Deniz Kirik MD, PhD Assistant Professor of Neurobiology

Published Online: 17 JUN 2005

DOI: 10.1002/3527603867.ch2

Neuroprotection: Models, Mechanisms and Therapies

Neuroprotection: Models, Mechanisms and Therapies

How to Cite

Romero-Ramos, M., Maingay, M. and Kirik, D. (2004) Parkinson's Disease, in Neuroprotection: Models, Mechanisms and Therapies (ed M. Bähr), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603867.ch2

Editor Information

  1. Department of Neurology, University of Göttingen Medical School, Robert-Koch-Str. 40, 37075 Göttingen, Germany

Author Information

  1. Wallenberg Neuroscience Center, Lund University, BMC A11, S-22184 Lund, Sweden

Publication History

  1. Published Online: 17 JUN 2005
  2. Published Print: 27 JUL 2004

ISBN Information

Print ISBN: 9783527308163

Online ISBN: 9783527603862



  • neuroprotection models;
  • mechanisms and therapies;
  • neurological disorders – epidemiology;
  • clinical overview;
  • model systems;
  • epidemiology of Parkinson's Disease (PD);
  • oxidative stress in Parkinson's Disease;
  • role of alpha-synuclein in Parkinson's Disease;
  • involvement of proteosome in PD;
  • neurotoxic PD models;
  • genetic models of Parkinson's Disease


This chapter contains sections titled:

  • Epidemiology of Parkinson's Disease

    • Genetic Contribution

    • Environmental Factors

  • Oxidative Stress In Parkinson's Disease

  • Role of Alpha-Synuclein in Parkinson's Disease

    • Alpha-Synuclein in Lewy Bodies

    • Alpha-Synuclein and Oxidative Stress

  • The Involvement of Proteosome in PD

    • Parkin Involvement in PD

  • Other Genes Involved in Familial Parkinson's Disease

  • Neurotoxic PD Models

    • Oxidative Stress

    • Dopamine Homeostasis/Complex I

    • Proteasome

  • Genetic Models of Parkinson's Disease

    • Alpha-Synuclein Overexpressing Transgenic Animals

    • Parkin-related Genetic Models

    • Viral Vectors for In Vivo Gene Transfer of Disease-related Proteins to the CNS

      • Local Overexpression of alpha-synuclein

      • Local Overexpression of Parkin-related Proteins

  • Acknowledgements

  • References