Chapter 7. Spinal Cord Injury

  1. Prof. Dr. Mathias Bähr
  1. Poonam Verma and
  2. James W. Fawcett

Published Online: 17 JUN 2005

DOI: 10.1002/3527603867.ch7

Neuroprotection: Models, Mechanisms and Therapies

Neuroprotection: Models, Mechanisms and Therapies

How to Cite

Verma, P. and Fawcett, J. W. (2005) Spinal Cord Injury, in Neuroprotection: Models, Mechanisms and Therapies (ed M. Bähr), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603867.ch7

Editor Information

  1. Department of Neurology, University of Göttingen Medical School, Robert-Koch-Str. 40, 37075 Göttingen, Germany

Author Information

  1. Brain Repair Centre, Cambridge University, Cambridge CB2 2PY, United Kingdom

Publication History

  1. Published Online: 17 JUN 2005
  2. Published Print: 27 JUL 2004

ISBN Information

Print ISBN: 9783527308163

Online ISBN: 9783527603862

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Keywords:

  • neuroprotection models;
  • mechanisms and therapies;
  • neurological disorders – epidemiology;
  • clinical overview;
  • spinal cord injury;
  • acute neuroprotection;
  • regeneration of nerve fiber tracts;
  • bridging cysts and scars and cellular replacement;
  • replacing lost neurons;
  • treating demyelination;
  • enhancing plasticity;
  • future expectations

Summary

This chapter contains sections titled:

  • Acute Neuroprotection (preventing neuronal death)

  • Regeneration of Nerve Fiber Tracts (initiating growth following injury)

    • Extrinsic Mechanisms

      • The Glial Scar

      • Blockage of Glial Scar Formation

      • Modification of Growth-inhibitory Molecules

      • Selective Removal of Astrocytes

    • Intrinsic Neuronal Control of Regeneration

      • Neuronal Age

      • Site of Transection

      • Neuronal Variability

  • Bridging Cysts and Scars and Cellular Replacement

  • Replacing Lost Neurons

    • Neural Transplantation

    • Replacing Lost Neurons from Stem Cells

  • Treating Demyelination

  • Enhancing Plasticity

  • Future Expectations

  • References