Chapter 1. Regulation of Porin Gene Expression by the Two-Component Regulatory System EnvZ/OmpR

  1. Prof. Dr. Roland Benz
  1. Don Walthers,
  2. Alvin Go and
  3. Linda J. Kenney

Published Online: 21 JUN 2005

DOI: 10.1002/3527603875.ch1

Bacterial and Eukaryotic Porins: Structure, Function, Mechanism

Bacterial and Eukaryotic Porins: Structure, Function, Mechanism

How to Cite

Walthers, D., Go, A. and Kenney, L. J. (2004) Regulation of Porin Gene Expression by the Two-Component Regulatory System EnvZ/OmpR, in Bacterial and Eukaryotic Porins: Structure, Function, Mechanism (ed R. Benz), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603875.ch1

Editor Information

  1. Lehrstuhl für Biotechnologie, Biozentrum der Universität Würzburg, Am Hubland, 97074 Würzburg, Germany

Author Information

  1. Department of Microbiology and Immunology, University of Illinois at Chicago, 835 S. Wolcott Avenue, Chicago, IL 60612, USA

Publication History

  1. Published Online: 21 JUN 2005
  2. Published Print: 27 JUL 2004

ISBN Information

Print ISBN: 9783527307753

Online ISBN: 9783527603879

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Keywords:

  • bacterial and eukaryotic porins;
  • regulation of porin gene expression;
  • structure of EnvZ;
  • biochemical activities of EnvZ;
  • OmpR subfamily;
  • OmpR binding sites;
  • affinity model of porin gene regulation

Summary

This chapter contains sections titled:

  • Introduction

  • The Structure of EnvZ

  • Biochemical Activities of EnvZ underlie Signaling

  • What is the EnvZ Activity Regulated by the Stimulus?

  • How is the Signal Propagated?

  • Is there a Role for Acetyl-phosphate in OmpR-P Production?

  • The OmpR Subfamily

  • OmpR Binding Sites

  • Recruitment of RNA Polymerase to OmpR-dependent Promoters

  • OmpR–RNAP Interaction Surface

  • Affinity Model of Porin Gene Regulation

  • A Test of the Affinity Model

  • Conformational Changes in OmpR Contribute to Differential Regulation of the Porin Genes

  • Other Factors that Regulate ompF and ompC

  • OmpR is a Global Regulator

    • Flagellar Biosynthesis

    • Curli Fimbriae Production

    • Virulence