Chapter 14. Mitochondrial Porins in Mammals: Insights into Functional Roles from Mutant Mice and Cells

  1. Prof. Dr. Roland Benz
  1. Keltoum Anflous and
  2. William J. Craigen

Published Online: 21 JUN 2005

DOI: 10.1002/3527603875.ch14

Bacterial and Eukaryotic Porins: Structure, Function, Mechanism

Bacterial and Eukaryotic Porins: Structure, Function, Mechanism

How to Cite

Anflous, K. and Craigen, W. J. (2004) Mitochondrial Porins in Mammals: Insights into Functional Roles from Mutant Mice and Cells, in Bacterial and Eukaryotic Porins: Structure, Function, Mechanism (ed R. Benz), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527603875.ch14

Editor Information

  1. Lehrstuhl für Biotechnologie, Biozentrum der Universität Würzburg, Am Hubland, 97074 Würzburg, Germany

Author Information

  1. Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA

Publication History

  1. Published Online: 21 JUN 2005
  2. Published Print: 27 JUL 2004

ISBN Information

Print ISBN: 9783527307753

Online ISBN: 9783527603879

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Keywords:

  • mitochondrial porins in mammals;
  • mutant mice and cells;
  • channel activity;
  • genetics of mammalian VDACs;
  • VDAC–cytoskeletal interactions;
  • mitochondrial permeability transition pore and synaptic functions;
  • VDACs and apoptosis

Summary

This chapter contains sections titled:

  • Introduction

  • Channel Activity

  • The Genetics of Mammalian VDACs

  • Generation of mammalian VDAC mutants

  • The Role of the Mitochondrial Outer Membrane in Compartmentalization of High-energy Metabolites

  • VDAC–Cytoskeletal Interactions

  • Mitochondrial Permeability Transition Pore and Synaptic Functions

  • VDACs and Apoptosis

  • Conclusions