Chapter 1. Introduction: RNA Interference, the “Breakthrough of the Year 2002”

  1. Dr. Ute Schepers

Published Online: 2 AUG 2005

DOI: 10.1002/3527604391.ch1

Book Title

RNA Interference in Practice

RNA Interference in Practice

Additional Information

How to Cite

Schepers, U. (2005) Introduction: RNA Interference, the “Breakthrough of the Year 2002”, in RNA Interference in Practice, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527604391.ch1

Author Information

  1. University of Bonn, Kekulé Institute for Organic Chemistry and Biochemistry, Gerhard-Domagk-Str. 1, 53121 Bonn, Germany

Publication History

  1. Published Online: 2 AUG 2005
  2. Published Print: 25 OCT 2004

ISBN Information

Print ISBN: 9783527310203

Online ISBN: 9783527604395

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Keywords:

  • RNA interference in practice;
  • gene silencing in C. elegans;
  • gene silencing in Drosophila;
  • gene silencing in mammals;
  • RNAi as a tool for functional genomics;
  • two classes of small RNAs;
  • RISC;
  • RNA polymerases (RdRps);
  • catalytic nature of RNAi

Summary

This chapter contains sections titled:

  • RNAi as a Tool for Functional Genomics

  • Mechanism of RNAi

  • Dicer – the Initiator to “Dice” the dsRNA?

  • miRNAs versus siRNAs: Two Classes of Small RNAs Using the RNAi Pathway?

  • RISC – the Effector to “Slice” the mRNA?

  • Are RNA-Dependent RNA Polymerases (RdRps) Responsible for the Catalytic Nature of RNAi?

  • Is RNAi Involved in the Regulation of Gene Expression?

  • RNAi in Mammals

  • Practical Approaches

  • References

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