Chapter 11. HGF/SF c-Met Signaling in the Epithelial–Mesenchymal Transition and Migration of Muscle Progenitor Cells

  1. Prof. Dr. Doris Wedlich
  1. Ute Schaeper1 and
  2. Walter Birchmeier2

Published Online: 9 AUG 2005

DOI: 10.1002/3527604669.ch11

Cell Migration in Development and Disease

Cell Migration in Development and Disease

How to Cite

Schaeper, U. and Birchmeier, W. (2004) HGF/SF c-Met Signaling in the Epithelial–Mesenchymal Transition and Migration of Muscle Progenitor Cells, in Cell Migration in Development and Disease (ed D. Wedlich), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527604669.ch11

Editor Information

  1. University of Karlsruhe, Institute of Zoology II, Kaiserstr. 12, 76131 Karlsruhe, Germany

Author Information

  1. 1

    Max-Delbrück Center for Molecular Medicine (MDC), Cancer Research Program, Robert Rössle Str. 10, 13092 Berlin, Germany

  2. 2

    Max-Delbrück-Center for Molecular Medicine (MDC), Robert Rössle Str. 10, 13125 Berlin, Germany

Publication History

  1. Published Online: 9 AUG 2005
  2. Published Print: 14 DEC 2004

ISBN Information

Print ISBN: 9783527305872

Online ISBN: 9783527604661

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Keywords:

  • cell migration;
  • HGF/SF c-Met signaling in the epithelial–mesenchymal transition;
  • migration of muscle progenitor cells;
  • hepatocyte growth factor/scatter factor (HGF/SF);
  • development of skeletal muscles;
  • migration of muscle progenitor cells;
  • evolution of migratory muscle progenitor cells

Summary

This chapter contains sections titled:

  • Introduction: Hepatocyte Growth Factor/scatter Factor (HGF/SF) is a Pleiotropic Growth Factor

  • HGF/SF is the Ligand for the Proto-oncogene c-Met

  • HGF/SF acts as a Paracrine Growth Factor in Normal Tissue

  • Functional Role of HGF/SF and c-Met in the Development of Skeletal Muscles

  • c-Met Substrates are Required for Migration of Muscle Progenitor Cells

  • Evolution of Migratory Muscle Progenitor Cells

  • Outlook

  • Acknowledgments

  • References