Chapter 16. From Tumorigenesis to Tumor Progression: Signaling Pathways Driving Tumor Invasion and Metastasis

  1. Prof. Dr. Doris Wedlich
  1. Klaudia Giehl1,
  2. Andre Menke2,
  3. Prof. Dr. Doris Wedlich3,
  4. Michael Beil2 and
  5. Thomas Seufferlein2

Published Online: 9 AUG 2005

DOI: 10.1002/3527604669.ch16

Cell Migration in Development and Disease

Cell Migration in Development and Disease

How to Cite

Giehl, K., Menke, A., Wedlich, D., Beil, M. and Seufferlein, T. (2004) From Tumorigenesis to Tumor Progression: Signaling Pathways Driving Tumor Invasion and Metastasis, in Cell Migration in Development and Disease (ed D. Wedlich), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527604669.ch16

Editor Information

  1. University of Karlsruhe, Institute of Zoology II, Kaiserstr. 12, 76131 Karlsruhe, Germany

Author Information

  1. 1

    University of Ulm, Department of Pharmacology and Toxicology, Albert-Einstein-Allee 11, 89081 Ulm, Germany

  2. 2

    University of Ulm, Department of Internal Medicine I, Robert Koch Str. 8, 89081 Ulm, Germany

  3. 3

    University of Karlsruhe, Institute of Zoology II, Kaiserstr. 12, 76131 Karlsruhe, Germany

Publication History

  1. Published Online: 9 AUG 2005
  2. Published Print: 14 DEC 2004

ISBN Information

Print ISBN: 9783527305872

Online ISBN: 9783527604661

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Keywords:

  • cell migration;
  • tumorigenesis;
  • tumor progression;
  • metastasis;
  • oncogenic Ras proteins;
  • signals controlling cellular adhesion complexes;
  • β-catenin;
  • HGF/SF signaling cascade;
  • bioactive lipids;
  • keratin regulation by sphingolipids;
  • sphingosylphosphorylcholine (SPC)

Summary

This chapter contains sections titled:

  • Introduction

  • Oncogenic Ras Proteins in Tumor Progression and Metasasis

    • Ras GTPases: Basic Properties

    • Oncogenic Ras Proteins: Signaling Specificity

    • Ras-mediated Signal Transduction in Tumorigenesis, Migration, and Invasion

      • Activation of the Raf-MEK-ERK Cascade

      • Extracellular Matrix Degradation

      • Activation of Phosphatidylinositol 3-Kinase and Rho GTPases

  • Signals Controlling Cellular Adhesion Complexes

    • Tyrosine Phosphorylation Induces E-cadherin/catenin Complex Disassembly

    • Extracellular Matrix-induced Inhibition of E-cadherin-mediated Cell Adhesion

    • The Protein p120ctn

  • Switching from Cellcell Adhesion to Migration: a Role for β-Catenin as Nuclear Wnt-signal Transducer?

    • The Contribution of Canonical Wnt/β-Catenin Signaling to Cell Migration

    • Is Non-canonical Wnt Signaling Important for Tumor Invasion and Tumor Cell Dissemination?

  • The HGF/SF Signaling Cascade Mediated via the c-Met Receptor

    • c-Met, RON and Alternate Receptors are Important for Motility Induction

    • Cellular Targets of HGF/SF Signaling in Cell Scattering

    • Bypassing Ligand Binding in c-Met Activation

  • Bioactive Lipids

    • The Receptors of Bioactive Lipids

    • Signal Transductions Pathways of Bioactive Lipids Stimulating Motility

  • Keratin Regulation by Sphingolipids – a Key to Metastasis?

    • Keratins Define the Structural Integrity and the Mechanical Properties of Epithelial Cells

    • Sphingosylphosphorylcholine: A Naturally Occurring Bioactive Lipid Regulating Multiple Biological Processes

    • SPC: A Promoter of Metastasis?

      • Keratin Reorganization in Epithelial Tumor Cells by SPC

      • SPC Treatment Changes Cell Shape Independently from other Cytoskeletal Components

      • SPC Changes the Elastic Properties of Epithelial Tumor Cells

      • SPC Facilitates Migration of Epithelial Tumor Cells through Size-limiting Pores

  • References