Chapter 2. Polarized Cell Motility: Microtubules Show the Way

  1. Prof. Dr. Doris Wedlich
  1. John Victor Small and
  2. Irina Kaverina

Published Online: 9 AUG 2005

DOI: 10.1002/3527604669.ch2

Cell Migration in Development and Disease

Cell Migration in Development and Disease

How to Cite

Small, J. V. and Kaverina, I. (2004) Polarized Cell Motility: Microtubules Show the Way, in Cell Migration in Development and Disease (ed D. Wedlich), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527604669.ch2

Editor Information

  1. University of Karlsruhe, Institute of Zoology II, Kaiserstr. 12, 76131 Karlsruhe, Germany

Author Information

  1. Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Dr Bohr-Gasse 7, 1030 Vienna, Austria

Publication History

  1. Published Online: 9 AUG 2005
  2. Published Print: 14 DEC 2004

ISBN Information

Print ISBN: 9783527305872

Online ISBN: 9783527604661

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Keywords:

  • cell migration;
  • polarized cell motility;
  • microtubules;
  • contractility;
  • kinesin and signal transmission;
  • microtubule dynamic;
  • microtubule guidance

Summary

This chapter contains sections titled:

  • Introduction

    • The Vasiliev Conundrum

    • Cell Polarity and Adhesion

  • Microtubules Meet the Actin Cytoskeleton at Focal Adhesions

  • Microtubule Targeting Promotes Focal Adhesion Turnover

  • Contractility, the Functional Link

  • Kinesin and Signal Transmission

  • Tip Complexes Meet Adhesion Complexes

  • Focal Adhesions Influence Microtubule Dynamic

  • Actin Talks Back: Tension and Microtubule Guidance

  • Conclusions and Perspectives

  • Acknowledgments

  • References