Chapter 4. Structural and Functional Aspects of the Mammalian Rod-Cell Photoreceptor Rhodopsin

  1. Prof. Dr. Winslow R. Briggs2 and
  2. Prof. Dr. John L. Spudich3
  1. Najmoutin G. Abdulaev1 and
  2. Kevin D. Ridge3

Published Online: 26 SEP 2005

DOI: 10.1002/352760510X.ch4

Handbook of Photosensory Receptors

Handbook of Photosensory Receptors

How to Cite

Abdulaev, N. G. and Ridge, K. D. (2005) Structural and Functional Aspects of the Mammalian Rod-Cell Photoreceptor Rhodopsin, in Handbook of Photosensory Receptors (eds W. R. Briggs and J. L. Spudich), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/352760510X.ch4

Editor Information

  1. 2

    Department of Plant Biology, Carnegie Institution of Washington, 260 Panama St., Stanford, CA 94305, USA

  2. 3

    Center for Membrane Biology, Department of Biochemistry & Molecular Biology, University of Texas Medical School, 6431 Fannin Street, MSB 6.130, Houston, TX 77030, USA

Author Information

  1. 1

    Center for Advanced Research in Biotechnology, University of Maryland Biotechnology Institute, 9600 Gudelsky Drive, Rockville, MD 20850 USA

  2. 3

    Center for Membrane Biology, Department of Biochemistry & Molecular Biology, University of Texas Medical School, 6431 Fannin Street, MSB 6.130, Houston, TX 77030, USA

Publication History

  1. Published Online: 26 SEP 2005
  2. Published Print: 17 FEB 2005

ISBN Information

Print ISBN: 9783527310197

Online ISBN: 9783527605101

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Keywords:

  • photosensory receptors;
  • rhodopsin;
  • mammalian rod-cell photoreceptor structural aspects;
  • functional;
  • mammalian visual phototransduction

Summary

This chapter contains sections titled:

  • Introduction

  • Rhodopsin and Mammalian Visual Phototransduction

    • Signal Amplification by Light-activated Rhodopsin

    • Inactivation of Light-activated Rhodopsin

  • Properties of Rhodopsin

    • Isolation of Rhodopsin

    • Biochemical and Physicochemical Properties of Rhodopsin

    • Post-translational Modifications in Rhodopsin

    • Membrane Topology of Rhodopsin and Functional Domains

  • Chromophore Binding Pocket and Photolysis of Rhodopsin

  • Structure of Rhodopsin

    • Crystal Structure of Rhodopsin

    • Atomic Force Microscopy of Rhodopsin in the Disk Membrane

  • Activation Mechanism of Rhodopsin

  • Conclusions

  • Acknowledgements

  • References