Chapter 1. Yeast Plasma-Membrane H+-ATPase: Model System for Studies of Structure, Function, Biogenesis, and Regulation

  1. Masamitsu Futai2,
  2. Yoh Wada3 and
  3. Jack H. Kaplan4
  1. Silvia Lecchi and
  2. Carolyn W. Slayman

Published Online: 6 DEC 2005

DOI: 10.1002/3527606122.ch1

Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology

Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology

How to Cite

Lecchi, S. and Slayman, C. W. (2004) Yeast Plasma-Membrane H+-ATPase: Model System for Studies of Structure, Function, Biogenesis, and Regulation, in Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology (eds M. Futai, Y. Wada and J. H. Kaplan), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527606122.ch1

Editor Information

  1. 2

    Division of Biological Sciences, Nanoscience and Nanotechnology Center, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan

  2. 3

    Division of Biological Sciences, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan

  3. 4

    University of Illinois at Chicago, Department of Biochemistry and Molecular Genetics, 900 S. Ashland Ave., Chicago, IL 60607, USA

Author Information

  1. Department of Genetics and Department of Cellular and Molecular Physiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA

Publication History

  1. Published Online: 6 DEC 2005
  2. Published Print: 24 JUN 2004

ISBN Information

Print ISBN: 9783527306893

Online ISBN: 9783527606122

SEARCH

Keywords:

  • ATPases;
  • P-type ATPases;
  • yeast plasma-membrane H+-ATPase;
  • structure;
  • Ca2+-ATPase;
  • reaction mechanism;
  • biogenesis;
  • regulation;
  • ATP binding and phosphorylation

Summary

This chapter contains sections titled:

  • Introduction

  • Structure

    • Ca2+-ATPase as a Model

    • Applicability of the Ca2+-ATPase Structure to Other P2-ATPases, Including the Pma1 H+-ATPase

    • H+-ATPase Oligomers

    • Associated Proteolipids

  • Reaction Mechanism

    • Overview of the Reaction Cycle

    • ATP Binding and Phosphorylation

    • E1–E2 Conformational Change

    • H+ Pumping

  • Biogenesis

    • Pma1 Mutants with Defects in Folding and Biogenesis

    • Use of Pma1 Mutants to Screen for Other Genes that Play a Role in Biogenesis and Quality Control

    • Role of Lipid Rafts

  • Regulation

  • Emerging Knowledge of Other Yeast P-type ATPases

  • Acknowledgments

  • References