Chapter 11. Coordinating Catalysis and Rotation in the F1-ATPase

  1. Masamitsu Futai2,
  2. Yoh Wada3 and
  3. Jack H. Kaplan4
  1. Robert K. Nakamoto,
  2. Nga Phi Le and
  3. Marwan K. Al-Shawi

Published Online: 6 DEC 2005

DOI: 10.1002/3527606122.ch11

Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology

Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology

How to Cite

Nakamoto, R. K., Le, N. P. and Al-Shawi, M. K. (2004) Coordinating Catalysis and Rotation in the F1-ATPase, in Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology (eds M. Futai, Y. Wada and J. H. Kaplan), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527606122.ch11

Editor Information

  1. 2

    Division of Biological Sciences, Nanoscience and Nanotechnology Center, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan

  2. 3

    Division of Biological Sciences, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan

  3. 4

    University of Illinois at Chicago, Department of Biochemistry and Molecular Genetics, 900 S. Ashland Ave., Chicago, IL 60607, USA

Author Information

  1. Department of Molecular Physiology and Biological Physics, University of Virginia Health Sciences Center, 1300 Jefferson Park Avenue, Charlottesville, VA 22908, USA

Publication History

  1. Published Online: 6 DEC 2005
  2. Published Print: 24 JUN 2004

ISBN Information

Print ISBN: 9783527306893

Online ISBN: 9783527606122

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Keywords:

  • ATPases;
  • F-type ATPases;
  • coordinating catalysis and rotation in F1-ATPase;
  • asymmetry of catalytic sites;
  • cooperative interactions;
  • promotion of catalysis;
  • steady-state rotational catalysis

Summary

This chapter contains sections titled:

  • Abbreviations

  • Introduction

  • Asymmetry of Catalytic Sites

    • Rotation Through Catalytic Site Conformations

  • Cooperative Interactions and the Promotion of Catalysis

    • Uni-site versus Multi-site Catalysis

    • Cooperative Promotion of Catalysis

    • Role of αArg376 in Multi-site Catalysis

  • Identification of a Rotation Step in Steady-state Catalysis

    • Rate-limiting Transition State Step

    • E. coli γM23K Mutation Perturbs Rotor–Stator Interactions

    • Isokinetic Analysis

    • Coupling Control and Modulation of Catalysis by the Rotor

  • Model for Steady-state Rotational Catalysis

  • Perspectives

  • Acknowledgments

  • References