Chapter 12. ATP Synthase Stalk Subunits b, δ and ε: Structures and Functions in Energy Coupling

  1. Masamitsu Futai2,
  2. Yoh Wada3 and
  3. Jack H. Kaplan4
  1. Stanley D. Dunn,
  2. Daniel J. Cipriano and
  3. Paul A. Del Rizzo

Published Online: 6 DEC 2005

DOI: 10.1002/3527606122.ch12

Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology

Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology

How to Cite

Dunn, S. D., Cipriano, D. J. and Del Rizzo, P. A. (2005) ATP Synthase Stalk Subunits b, δ and ε: Structures and Functions in Energy Coupling, in Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology (eds M. Futai, Y. Wada and J. H. Kaplan), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527606122.ch12

Editor Information

  1. 2

    Division of Biological Sciences, Nanoscience and Nanotechnology Center, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan

  2. 3

    Division of Biological Sciences, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan

  3. 4

    University of Illinois at Chicago, Department of Biochemistry and Molecular Genetics, 900 S. Ashland Ave., Chicago, IL 60607, USA

Author Information

  1. Department of Biochemistry, University of Western Ontario, 1151 Richmond Street, London, Ontario N6A 5C1, Canada

Publication History

  1. Published Online: 6 DEC 2005
  2. Published Print: 24 JUN 2004

ISBN Information

Print ISBN: 9783527306893

Online ISBN: 9783527606122

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Keywords:

  • ATPases;
  • F-type ATPases;
  • ATP synthase stalk subunits b;
  • δ and ε;
  • structures and functions in energy coupling;
  • ε subunit of ATP synthase;
  • peripheral stalk of ATP synthase;
  • structure of δ;
  • interaction of b and δ

Summary

This chapter contains sections titled:

  • Introduction

  • ε Subunit of ATP Synthase

    • Conformations of the ε Subunit in Crystal Structures of ATP Synthase and the γ′ε Subcomplex

      • ε in the “Down” Conformation

      • ε in the “Up” Conformation

    • Biochemical Analyses of Conformations and Orientations of ε in ATP Synthase

    • Role of the ε Subunit in ATP Synthase

      • Rotation of ε During Hydrolysis

      • Role of ε in the Formation of F1Fo and Inhibition of Soluble F1-ATPase

      • ε as an Inhibitor in ATP Synthase

      • Bidirectional Ratchet Model for ε Function in ATP Synthase

  • Peripheral Stalk of ATP Synthase

    • b Subunit Sequences

    • Structure of E. coli b

      • Membrane-spanning Domain

      • Tether Domain

      • Dimerization Domain

      • δ-Binding Domain

      • Proposed Structural Model of b

    • Structure of δ

    • Interaction of b and δ

    • Position of the Peripheral Stalk in ATP Synthase

    • Function of the Peripheral Stalk

  • Conclusion

  • References