Chapter 14. Role of the V-ATPase in the Cellular Physiology of the Yeast Saccharomyces cerevisiae

  1. Masamitsu Futai3,
  2. Yoh Wada4,
  3. Jack H. Kaplan5
  1. Laurie A. Graham1,
  2. Katherine Bowers2,
  3. Andrew R. Flannery2,
  4. Tom H. Stevens1

Published Online: 6 DEC 2005

DOI: 10.1002/3527606122.ch14

Book Title

Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology

Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology

Additional Information

How to Cite

Graham, L. A., Bowers, K., Flannery, A. R. and Stevens, T. H. (2005) Role of the V-ATPase in the Cellular Physiology of the Yeast Saccharomyces cerevisiae, in Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology (eds M. Futai, Y. Wada and J. H. Kaplan), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527606122.ch14

Editor Information

  1. 3

    Division of Biological Sciences, Nanoscience and Nanotechnology Center, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan

  2. 4

    Division of Biological Sciences, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan

  3. 5

    University of Illinois at Chicago, Department of Biochemistry and Molecular Genetics, 900 S. Ashland Ave., Chicago, IL 60607, USA

Author Information

  1. 1

    Institute of Molecular Biology, University of Oregon, Eugene, OR 97403-1229, USA

  2. 2

    Cambridge Institute for Medical Research and Department of Clinical Biochemistry, University of Cambridge, Addenbrookes Hospital, Hills Road, Cambridge CD2 2XY, United Kingdom

Publication History

  1. Published Online: 6 DEC 2005
  2. Published Print: 24 JUN 2004

ISBN Information

Print ISBN: 9783527306893

Online ISBN: 9783527606122

SEARCH

CHAPTER TOOLS

Get PDF (282K)

Keywords:

  • ATPases;
  • V-type ATPases;
  • role in the cellular physiology;
  • Saccharomyces cerevisiae;
  • acidification of yeast vacuole;
  • function and structure yeast V-ATPase;
  • V1 catalytic domain;
  • Vo domain;
  • regulation of V-ATPase function;
  • targeting and trafficking;
  • role in protein trafficking

Summary

This chapter contains sections titled:

  • Introduction: the Yeast V-ATPase

  • Role of the V-ATPase in the Acidification of the Yeast Vacuole

  • Overview of the Function and Structure of the Yeast V-ATPase

  • Composition and Assembly of the V1 Catalytic Domain of the Yeast V-ATPase

  • Composition of the Proton-translocating Domain of the Yeast V-ATPase

  • Assembly of the Vo Domain Occurs in the ER and Requires Dedicated Assembly Factors

  • Regulation of V-ATPase Function in Yeast

  • Targeting and Trafficking of the Yeast V-ATPase (Vph1p vs. Stv1p)

  • Alternative Mechanisms for Intraorganellar Acidification in the Absence of the V-ATPase

  • Role of the V-ATPase in Protein Trafficking

  • Conclusion

  • References

Get PDF (282K)