Chapter 15. Vacuolar-Type Proton ATPases: Subunit Isoforms and Tissue-Specific Functions

  1. Masamitsu Futai1,
  2. Yoh Wada2 and
  3. Jack H. Kaplan3
  1. Ge-Hong Sun-Wada1,
  2. Masamitsu Futai1 and
  3. Yoh Wada2

Published Online: 6 DEC 2005

DOI: 10.1002/3527606122.ch15

Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology

Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology

How to Cite

Sun-Wada, G.-H., Futai, M. and Wada, Y. (2004) Vacuolar-Type Proton ATPases: Subunit Isoforms and Tissue-Specific Functions, in Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology (eds M. Futai, Y. Wada and J. H. Kaplan), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527606122.ch15

Editor Information

  1. 1

    Division of Biological Sciences, Nanoscience and Nanotechnology Center, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan

  2. 2

    Division of Biological Sciences, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan

  3. 3

    University of Illinois at Chicago, Department of Biochemistry and Molecular Genetics, 900 S. Ashland Ave., Chicago, IL 60607, USA

Author Information

  1. 1

    Division of Biological Sciences, Nanoscience and Nanotechnology Center, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan

  2. 2

    Division of Biological Sciences, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan

Publication History

  1. Published Online: 6 DEC 2005
  2. Published Print: 24 JUN 2004

ISBN Information

Print ISBN: 9783527306893

Online ISBN: 9783527606122

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Keywords:

  • ATPases;
  • V-type ATPases;
  • vacuolar-type proton ATPases;
  • subunit isoforms;
  • tissue-specific functions;
  • V- and F-ATPase similarities;
  • mammalian development;
  • V-ATPase;
  • tissue-specific functions of V-ATPase;
  • subunit isoform

Summary

This chapter contains sections titled:

  • Similarities Between V- and F-ATPase

  • V-ATPase is Essential for Mammalian Development

  • Subunit Isoform Involved in Tissue-specific Functions of V-ATPase

    • V-ATPase and Osteoclasts

    • Kidney-specific Isoforms and Distal Renal Tubular Acidosis

    • Brain-specific Isoform G2

    • E1 Isoform and Acidification of Acrosome

    • C2-a Subunit Isoform and Acidification of Lamellar Bodies in Type II Alveolar Cells

  • Future Perspectives

  • References