Chapter 16. Physiological Role of Na,K-ATPase Isoforms

  1. Masamitsu Futai2,
  2. Yoh Wada3 and
  3. Jack H. Kaplan4
  1. Jerry B Lingrel,
  2. Jonathan Neumann,
  3. Iva Dostanic and
  4. Amy E. Moseley

Published Online: 6 DEC 2005

DOI: 10.1002/3527606122.ch16

Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology

Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology

How to Cite

Lingrel, J. B., Neumann, J., Dostanic, I. and Moseley, A. E. (2004) Physiological Role of Na,K-ATPase Isoforms, in Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology (eds M. Futai, Y. Wada and J. H. Kaplan), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527606122.ch16

Editor Information

  1. 2

    Division of Biological Sciences, Nanoscience and Nanotechnology Center, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan

  2. 3

    Division of Biological Sciences, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan

  3. 4

    University of Illinois at Chicago, Department of Biochemistry and Molecular Genetics, 900 S. Ashland Ave., Chicago, IL 60607, USA

Author Information

  1. Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati, 231 Albert Sabin Way, Cincinnati, OH 45267-0524, USA

Publication History

  1. Published Online: 6 DEC 2005
  2. Published Print: 24 JUN 2004

ISBN Information

Print ISBN: 9783527306893

Online ISBN: 9783527606122

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Keywords:

  • ATPases;
  • cell biology;
  • pathophysiology of ATPases;
  • compartments;
  • physiological role of Na,K-ATPase isoforms;
  • α isoforms;
  • β isoforms;
  • non-transport function of the Na,K-ATPase;
  • in vivo studies;
  • differential isoform function;
  • differential function of the α1 isoform and the α2;
  • α3 and α4 isoforms;
  • Na,K-ATPase isoforms and disease

Summary

This chapter contains sections titled:

  • Introduction

  • α Isoforms

  • β Isoforms

  • Physiological Role of Na,K-ATPase Isoforms

    • Duplication and Divergence of α and β Isoform Genes

    • Enzymatic Properties of α and β Isoform Genes

    • Differential Expression of α and β Isoform Genes

  • Non-transport Function of the Na,K-ATPase

  • In Vivo Studies of Differential Isoform Function

    • Gene Knock-out of the β2 Isoform

    • Gene Replacement of the β2 Isoform with β1

    • Overexpression of the α2 Isoform

    • Gene Knock-out of the α1 and α2 Isoform Genes

  • Model for Differential Function of the α1 Isoform and the α2, α3 and α4 Isoforms

  • Na,K-ATPase Isoforms and Disease

    • Migraine Headache and the α2 Isoform

  • Acknowledgments

  • References