Chapter 2. Regulation of the Sarco(endo)plasmic Reticulum Ca2+-ATPase by Phospholamban and Sarcolipin

  1. Masamitsu Futai3,
  2. Yoh Wada4 and
  3. Jack H. Kaplan5
  1. David H. McLennan1 and
  2. Evangelia G. Kranias2

Published Online: 6 DEC 2005

DOI: 10.1002/3527606122.ch2

Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology

Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology

How to Cite

McLennan, D. H. and Kranias, E. G. (2005) Regulation of the Sarco(endo)plasmic Reticulum Ca2+-ATPase by Phospholamban and Sarcolipin, in Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology (eds M. Futai, Y. Wada and J. H. Kaplan), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527606122.ch2

Editor Information

  1. 3

    Division of Biological Sciences, Nanoscience and Nanotechnology Center, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan

  2. 4

    Division of Biological Sciences, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan

  3. 5

    University of Illinois at Chicago, Department of Biochemistry and Molecular Genetics, 900 S. Ashland Ave., Chicago, IL 60607, USA

Author Information

  1. 1

    Banting and Best Department of Medical Research, University of Toronto, Toronto, Ontario M5G 1L6, Canada

  2. 2

    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA

Publication History

  1. Published Online: 6 DEC 2005
  2. Published Print: 24 JUN 2004

ISBN Information

Print ISBN: 9783527306893

Online ISBN: 9783527606122

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Keywords:

  • ATPases;
  • P-type ATPases;
  • regulation of the sarco(endo)plasmic reticulum Ca2+-ATPase;
  • phospholamban (PLN);
  • physiological role;
  • phospholamban in heart failure;
  • human PLN mutations;
  • cardiomyopathy;
  • sarcolipin (SLN);
  • physiological role of SLN

Summary

This chapter contains sections titled:

  • Introduction

    • Background to Ca2+ Signaling

    • β-Adrenergic Signaling in the Heart

  • Phospholamban–SERCA Interactions

    • SERCA Structure and Function

    • PLN Structure and Function

    • Approaches to the Study of PLN–SERCA Interactions

    • SERCA Residues Essential for Cytoplasmic Interaction with PLN

    • PLN Residues Essential for Cytoplasmic Interaction with SERCA

    • PLN Residues Essential for Transmembrane Interactions with SERCA

    • SERCA Residues Essential for Transmembrane Interactions with PLN

    • Structural Modeling of the PLN–SERCA Inhibitory Interaction

  • Physiological Role of PLN in Basal Cardiac Function

    • Alterations in PLN Levels and Function by Transcription and Phosphorylation

    • Targeting of PLN

    • Role of PLN in Smooth and Skeletal Muscles

    • Overexpression of PLN

    • Physiological Role of PLN in b-Adrenergic Stimulation

    • Superinhibitory PLN Mutants

  • Phospholamban in Heart Failure

    • Introduction

    • Potential Therapies

  • Human PLN Mutations as a Cause of Cardiomyopathy

    • PLN R9C Mutant

    • PLN L39stop Mutant

  • Sarcolipin

    • Introduction

  • Physiological Role of SLN

    • SLN Expression

    • Overexpression of SLN

      • Response of the SLN Gene to Chronic Stimulation

    • Inhibition of SERCA Function by SLN Plus PLN

    • Modeling of the SLN-SERCA and SLN-PLN–SERCA Interactions

  • Acknowledgments

  • References