Chapter 3. Catalytic and Transport Mechanism of the Sarco-(Endo)Plasmic Reticulum Ca2+-ATPase (SERCA)
- Masamitsu Futai3,
- Yoh Wada4,
- Jack H. Kaplan5
Published Online: 6 DEC 2005
DOI: 10.1002/3527606122.ch3
Copyright © 2004 Wiley-VCH Verlag GmbH & Co. KGaA
Book Title
Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology
Additional Information
How to Cite
Inesi, G. and Toyoshima, C. (2005) Catalytic and Transport Mechanism of the Sarco-(Endo)Plasmic Reticulum Ca2+-ATPase (SERCA), in Handbook of ATPases: Biochemistry, Cell Biology, Pathophysiology (eds M. Futai, Y. Wada and J. H. Kaplan), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, FRG. doi: 10.1002/3527606122.ch3
Editor Information
- 3
Division of Biological Sciences, Nanoscience and Nanotechnology Center, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan
- 4
Division of Biological Sciences, Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan
- 5
University of Illinois at Chicago, Department of Biochemistry and Molecular Genetics, 900 S. Ashland Ave., Chicago, IL 60607, USA
Publication History
- Published Online: 6 DEC 2005
- Published Print: 24 JUN 2004
ISBN Information
Print ISBN: 9783527306893
Online ISBN: 9783527606122
- Summary
- Chapter
Keywords:
- ATPases;
- P-type ATPases;
- catalytic mechanism;
- transport mechanism;
- sarco-(endo)plasmic reticulum Ca2+-ATPase (SERCA);
- functional characterization;
- structural characterization;
- binding of ligands;
- conformational changes
Summary
This chapter contains sections titled:
Summary
Introduction
Experimental Systems
Functional Characterization
Structural Characterization
Extramembranous Region and the Catalytic Domains of E1·2Ca2+
Transmembrane region of E1·2Ca2+
Enzyme Structure in the Absence of Ca2+ (E2·TG)
Thapsigargin-binding Domain
Interaction with Phospholamban
Binding of Ligands, Catalytic Events and Conformational Changes
Ca2+ Binding and Catalytic Activation
Nucleotide Binding and Substrate-induced Conformational Fit
Phosphoryl Transfer and Hydrolytic Cleavage
Interconversion of Phosphorylation and Ca2+ Binding Potentials
References